In a nutshell The study evaluated outcomes of tandem autologous stem cell transplantation (ASCT) – reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) in patients with high-risk (HR) relapsed Hodgkin lymphoma (HL). The main finding was that this approach was safe and effective in such patients. Some...
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In a nutshell This study compared stem cell transplants (SCT) from identical donors to half-matched donors in patients with Hodgkin Lymphoma (HL). The study found that patients who received a transplant from a half-matched donor had a better response and survival without cancer progression. Some background HL is a type of blood cancer. One...
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In a nutshell This study aimed to compare autologous stem cell transplant (ASCT) and conventional chemotherapy (CT) as second-line treatments in patients with relapsed early-stage (ES), classical Hodgkin lymphoma (cHL). This study concluded that CT treatments may be a suitable second-line treatment option for patients...
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In a nutshell This study aimed to investigate the safety and effectiveness of brentuximab vedotin (BV; Adcetris) and nivolumab (Opdivo) in older patients with Hodgkin lymphoma (HL) or younger patients unsuitable for standard treatment. This study concluded that this treatment may benefit these...
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In a nutshell This study aimed to investigate the outcomes of a second hematopoietic stem cell transplant (HSCT) after reduced-intensity conditioning (RIC) for patients with leukemia or lymphoma. This study concluded that this treatment path is feasible and a good treatment alternative for these patients. Some background...
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In a nutshell This study aimed to investigate the safety and effectiveness of pembrolizumab (Keytruda) followed by AVD (doxorubicin, vinblastine, and dacarbazine) treatment in patients with high-risk classical Hodgkin lymphoma. This study concluded that this treatment was safe and effective in these patients. Some...
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In a nutshell The purpose of this study was to assess the dose of radiation delivered to organs at risk with modern radiotherapy (RT) in patients with early-stage Hodgkin lymphoma (HL). The authors found that 2 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and 20Gy of RT for early-stage HL was highly effective...
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In a nutshell The study evaluated outcomes of anti-programmed cell death-1 monoclonal antibodies (anti-PD-1-mAbs or APMs) before and after allogeneic hematopoietic cell transplantation (alloHCT) for patients with relapsed/refractory Hodgkin lymphoma (r/r-HL). The authors found that patients receiving APMs before alloHCT had frequent immune-related...
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In a nutshell This study was carried out to assess the safety and effectiveness of a chemotherapy regimen including gemcitabine (Gemzar) and vinorelbine (Navelbine) for relapsed childhood Hodgkin lymphoma (HL). The authors found that this regimen is effective in treating childhood HL in the outpatient setting and there was low...
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In a nutshell The study evaluated real-life benefits of autologous hematopoietic stem cell transplantation (ASCT) after immune checkpoint inhibitor (CPi) therapy in patients with relapsed/refractory (r/r) Hodgkin lymphoma (HL). The authors found that ASCT can be an effective option after CPi therapy in such patients. Some background Some patients...
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In a nutshell This study aimed to investigate the association between total body irradiation and further breast cancer diagnosis in patients treated with blood or marrow transplantation for leukemia-lymphoma. This study concluded that there is an association between the total body irradiation and an increased risk of breast cancer in...
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In a nutshell The study evaluated the impact of consolidation radiotherapy (cRT) on patients with advanced Hodgkin lymphoma (HL) who had large nodal mass (LNM) and currently in complete metabolic response (CMR) after receiving ABVD chemotherapy. The authors found that cRT could be safely avoided in such patients. Some background CMR defines...
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