In a nutshell This study investigated certain drugs (SGLT2 inhibitors) that control blood sugars to see if they caused an increased risk of bone fractures (breakages) in type 2 diabetic patients. The study found no association between the drugs and bone fractures. Some background Patients with type 2 diabetes (T2D) are at a high risk of bone...
Read MoreIn a nutshell The main objective of this trial is to determine the effectiveness and durability of a combined group of drugs (exenatide [Byetta], pioglitazone [Actos] and metformin [Glucophage]) compared to standard treatment in type 2 diabetes. The main outcome to be measured will be the change in HbA1c (average blood glucose over 3 months). The...
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In a nutshell This study looked at saxagliptin (Onglyza) in Japanese patients with type 2 diabetes (T2D) who were undergoing hemodialysis. They found that saxagliptin was effective at controlling blood glucose and was not associated with side effects. Some background Blood glucose control is difficult for T2D patients on hemodialysis...
Read MoreIn a nutshell This study compared additional treatment options for patients with uncontrolled type 2 diabetes (T2D) currently taking basal insulin and other oral anti-diabetic drugs (OADs). They concluded that lixisenatide (Lyxumia and Adlyxin) may be a preferable option to insulin with meals. Some background One treatment option for T2D is...
Read MoreIn a nutshell This study investigated whether type 2 diabetes patients were at increased risk of weight gain when starting insulin treatment. Weight gain differed depending on the patient’s weight when starting insulin treatment. Some background Type 2 diabetes is a progressive disease where the cells in the pancreas that produce insulin,...
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In a nutshell This study looked at the effect of diet on glycemic (blood glucose) control in young patients with type 1 diabetes (T1D). It was found that diets higher in whole grain, high fiber, low glycemic index (GI) carbohydrates, fruits, vegetables and natural sugars may help to control blood glucose. Some background Diet and nutrition...
Read MoreIn a nutshell The main objective of this trial is to determine the safety and efficacy of dapagliflozin (Farxiga) in type 2 diabetes patients aged 10-24 years. The main outcome to be measured is the change in average blood glucose (sugar) levels. The details Dapagliflozin is a type 2 diabetes treatment that removes glucose from the blood and...
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In a nutshell This study examined the relationship between the presence and severity of diabetes-related eye conditions and symptoms of anxiety and depression. The authors found that severe diabetic retinopathy (DR) and moderate to severe vision loss were associated with greater symptoms of depression. Some background Higher rates of anxiety...
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In a nutshell This study looked at the effect of empaglifozin (Jardiance) on kidney disease progression in patients with type 2 diabetes (T2D). They found that empaglifozin was associated with a slower rate of kidney disease progression and reduced risk of development of kidney related disease. Some background Empaglifozin is a drug which...
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In a nutshell This study investigated whether adding dapagliflozin (Farxiga/Forxiga) to liraglutide (Victoza) and insulin therapy would improve blood glucose control and promote weight loss in patients with type 1 diabetes (T1D). Improved blood glucose control and weight loss was recorded, however increased ketosis (raised ketone acids in the blood)...
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In a nutshell This study aimed to determine the relationship between metformin (Glucophage) use in older adults with diabetes and vitamin B-12 concentrations, and assess whether B-12 supplementation can alter this. Metformin use was shown to be linked to lower B-12 levels, and multivitamin use may be protective against this. Some background...
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In a nutshell This study examined the risk factors associated with a first heart attack in diabetes. This study showed that physical activity and body weight were associated with the risk of a first heart attack. Some background Diabetes is associated with a twofold increase in the risk of heart attack. It has been shown that physical activity and...
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