In a nutshell The aim of this study was to compare the effects of switching from pioglitazone to dapagliflozin on body weight and blood glucose control in the treatment of type 2 diabetes (T2D). The main finding was that there was greater weight loss seen with dapagliflozin, with similar blood glucose control. Some background In T2D,...
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Anti-vascular endothelial growth factor (anti-VEGF) drugs for diabetic eye disease
In a nutshell The aim of this study was to evaluate anti-vascular endothelial growth factor (anti-VEGF) drugs for diabetic macular oedema. The main finding of the study was that these drugs prevent loss of sight and improve vision in these patients. Some background Patients with diabetes are at risk of developing an eye disease called...
Read MoreLooking for patients with diabetic foot ulcers to test a new gel on ulcer healing
In a nutshell This trial is examining the effectiveness of autologous platelet-rich plasma (PRP) gel in the treatment of diabetic foot ulcers. The main outcome to be measured is the number of patients with complete wound closure. This study is being conducted in the United States. The details Diabetic foot ulcers (DFU) are a common complication of...
Read MorePramlintide and insulin together improves blood sugar control in type 1 diabetes
In a nutshell The aim of this study was to investigate the effectiveness of pramlintide (Symlin) with insulin on blood glucose control in a 24-hour period. The main finding of the study was that pramlintide improved blood glucose after meals and reduced the fluctuation in blood glucose levels in patients with type 1 diabetes (T1D). Some...
Read MoreHow effective is botulinum toxin-A for treating cramps in diabetic nerve disease?
In a nutshell The aim of this study was to investigate the safety and effectiveness of botulinum toxin A (BTX-A) injections for treating muscle cramps in diabetic neuropathy (nerve disease). The main finding of this study was that this treatment was safe and effective in treating muscle cramps in diabetic neuropathy. Some background Diabetic...
Read MoreRisk factors associated with nonalcoholic fatty liver disease in patients with type 2 diabetes
In a nutshell The aim of this study was to investigate the occurrence of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2D). The main finding of the study was that T2D patients who are older, who smoke and have high body weight and diastolic blood pressure are more likely to develop NAFLD. Some background T2D is commonly...
Read MoreSearching for patients with painful diabetic nerve disease to test if spinal cord stimulation can reduce pain
In a nutshell This trial is examining the effectiveness of spinal cord stimulation (SCS) on improving nerve function and pain in patients with diabetic nerve disease. The main outcome to be measured will be a change in pain levels, symptoms, and functions. This study is being conducted at the Mayo Clinic in Rochester, Minnesota, United...
Read MoreLooking for patients with prediabetes to test the effect of high protein diet on weight loss and blood glucose control
In a nutshell The aim of the trial is to examine the impact of high protein intake (from eggs) with calorie restriction on weight loss and insulin resistance in patients with prediabetes. The main outcomes to be measured will be weight loss and blood glucose and insulin levels. This study is being conducted in the United States, North Carolina. The...
Read MoreCan non-insulin diabetic drugs benefit overweight adults with type 1 diabetes?
In a nutshell This study aimed to see if non-insulin diabetic drugs could improve weight loss and blood glucose control in patients with type 1 diabetes (T1D). The main finding of the study was that non-insulin diabetic drugs may be of some benefit to overweight patients with T1D. Some background T1D is treated with insulin. However, the side effects...
Read MoreLiraglutide reduces risk of heart disease in type 2 diabetes
In a nutshell This study aimed to investigate the effect of liraglutide on heart disease in type 2 diabetes (T2D). The main finding of the study was that compared to DPP-4 inhibitors, liraglutide significantly reduced the risk of heart disease in patients with T2D. Some background Patients with T2D have a higher risk of heart disease. Therefore, there...
Read MoreCan good blood glucose control stop the stiffening of blood vessels in patients with diabetes?
In a nutshell The aim of this study was to investigate if optimal blood glucose control reduces the stiffening (calcification) of the arteries of the heart in patients with diabetes. The main finding of the study was that optimal blood sugar control stopped the calcification of the arteries of the heart. Some background Calcifications appear when...
Read MoreIs there a better time to reduce basal insulin before exercise to prevent hypoglycemia?
In a nutshell The aim of this study was to compare three different times to decrease basal insulin to reduce hypoglycemia after exercise in patients with type 1 diabetes. The main finding of the study was that reducing basal insulin by 80% up to 40 minutes before exercise still did not reduce exercise-induced hypoglycemia. Some background Insulin is...
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