In a nutshell This study evaluated the safety and effectiveness of two chemotherapy regimens (SOX and mFOLFOX6) before surgery for rectal cancer (RC) without radiotherapy. The study found that both regimens were safe and effective in these patients. Some background RC is commonly treated with surgery to remove the tumor. Patients with...
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In a nutshell This study evaluated reasons for a delay to ileostomy closure in patients who underwent anterior resection for rectal cancer. This study showed that factors such as having chemotherapy or cancer progression may delay ileostomy closure. Some background The go-to surgical treatment for cancer of the middle and lower rectum involves...
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In a nutshell This study compared the use of chemotherapy and bevacizumab (Avastin) or panitumumab (Vectibix) for the treatment of left-sided metastatic colorectal cancer (mCRC) without BRAF/RAS mutations (permanent changes in genes). The study found that both treatment options are effective for these patients. Some background Patients who...
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In a nutshell This article looked at the effectiveness of bevacizumab (Avastin) with chemotherapy for metastatic colorectal cancer (mCRC) in a real-world setting. The authors found that the addition of bevacizumab to chemotherapy regimens provides survival benefits in patients who cannot undergo curative local treatment. Some background...
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In a nutshell This study compared the use of pembrolizumab (Keytruda) to chemotherapy for the treatment of patients with colorectal cancer (CRC) and high microsatellite instability (MI). This study showed that patients who received pembrolizumab had a better outcome than those who were given chemotherapy. Some background Patients who are...
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In a nutshell This study compared the effectiveness of regorafenib (Stivarga), trifluridine/tipiracil (TFTP; Lonsurf), and combinations of these drugs in the treatment of patients with inoperable colorectal cancer. Researchers suggested that a combination of TFTP and regorafenib is associated with longer survival and fewer side effects. Some...
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In a nutshell This study investigated the long-term outcomes of patients with colorectal cancer (CRC) and liver metastases (LM; cancer spread to the liver) undergoing the ALPPS (associating liver partition and portal vein ligation) procedure. Researchers suggested that patients with LM that were unfit for surgical removal achieved positive long-term...
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In a nutshell The study evaluated the optimal timing of surgery for colorectal cancer liver metastasis (CRLM) after chemotherapy (CT). The main finding was that surgery within 5 weeks after CT may improve patients' outcomes. Some background Chemotherapy (CT) is used before surgery to remove tumors to reduce tumor size. This is...
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In a nutshell This study compared 3 and 6 months of oxaliplatin (Eloxatin)-based chemotherapy in stage 2 colon cancer. Researchers suggested that the 3-month treatment might be a good and safer option for these patients. Some background Colorectal cancer is the third most common cancer diagnosed in both men and women in the US. Chemotherapy after...
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In a nutshell This study investigated the effectiveness of bevacizumab plus chemotherapy and deep electro-hyperthermia (DEH) for advanced colon cancer (CC). Researchers suggested that this treatment improves the outcomes of these patients. Some background Colorectal cancer is a common cancer worldwide. Around 50-60% of these patients...
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In a nutshell This study investigated the effectiveness of irinotecan (Camptosar) with and without cetuximab (Erbitux) in the treatment of metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that combined treatment improves the outcomes of these patients. Some background Colorectal cancer (CRC) is one of...
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In a nutshell This study investigated the outcomes of patients with colorectal cancer who underwent robotic surgery. Researchers suggested that the da Vinci robotic system improved the surgery outcomes of these patients. Some background Rectal cancer accounts for around 30% of all colorectal cancers. Surgery is the standard method of...
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