In a nutshell This trial is examining the effectiveness of a new cancer vaccine. The main outcomes to be measured are cancer response and side effects. This trial is recruiting in New York and Tennessee, US. The details The standard treatment for most cancers is surgery and chemotherapy. However, chemotherapy has a limited effectiveness and a high...
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In a nutshell This study investigated the complications after colorectal cancer (CRC) surgery in elderly patients. Researchers suggested that if the patient is fit enough to undergo surgery, it improves the cancer outcomes. Some background CRC is the most common cancer in elderly people. The standard treatment for CRC is surgery and chemotherapy, if...
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In a nutshell This study investigated the effectiveness of chemotherapy and radiation therapy (CRT) with capecitabine (Xeloda) before surgery in elderly patients with locally advanced rectal cancer. Researchers suggested that this treatment is safe and well tolerated in the elderly. Some background Colorectal cancer is the third most commonly...
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In a nutshell This study investigated the relationship between changes in the levels of carcinoembryonic antigen (CEA) and colorectal cancer response to treatment. Researchers suggested that CEA levels are associated with tumor response and can be used as a prognostic factor. Some background In 2014 the European Society for Medical Oncology...
Read MoreIn a nutshell This study aimed to investigate two techniques used to treat low rectal cancer, abdominoperineal resection (APR) and intersphincteric resection (ISR). This study found there was no significant difference in long-term outcomes for APR and ISR. Some background APR is a common surgery to remove low rectal cancers. A low rectal...
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In a nutshell This study investigated the effects of home-based physical exercise (PE) on the quality of life of patients with colorectal cancer. Researchers suggested that this program may improve the mental health and quality of life of these patients. Some background Early diagnosis and new therapies have improved the survival rates of patients...
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In a nutshell This phase 3 trial is examining the effectiveness of arfolitixorin versus leucovorin (folinic acid) when added to a combined treatment with 5-fluorouracil, oxaliplatin, and bevacizumab (FOB) to treat advanced colorectal cancer. The main outcome to be measured is the cancer response to the treatment. The details Treatment with...
Read MoreIn a nutshell This study investigated the effectiveness and safety of treatment with regorafenib (Stivarga) followed by cetuximab (Erbitux) in the treatment of advanced colorectal cancer. Researchers suggested that this treatment improves survival of these patients. Some background New treatments have become available in the past 20 years to treat...
Read MoreIn a nutshell This study investigated the effectiveness of hypofractionated stereotactic radiotherapy (HSR; high doses of radiation given in fewer sessions than conventional radiotherapy) in advanced colorectal cancer. Researchers suggested that HSR is associated with improved outcomes and manageable side effects. Some background Colorectal cancer is...
Read MoreIn a nutshell This phase 2 trial is investigating the effectiveness of a treatment combination to treat metastatic (spread to other parts of the body) colorectal cancer that has not responded to prior therapy. The main outcome to be measured is response to treatment on imaging. This trial is taking place in Colorado, United...
Read MoreIn a nutshell This study investigated the relationship between lymphocyte (a type of white blood cells) counts and treatment outcomes for patients with rectal cancer. Researchers suggested that lymphocyte count reduction may be caused by rectal cancer treatment and is associated with better tumor response. Some background Colorectal cancer is the...
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In a nutshell This phase 3 trial is examining the effectiveness of a combination treatment with panitumumab (Vectibix), leucovorin and fluorouracil after chemotherapy combined with panitumumab in metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is progression-free survival (PFS; time from treatment to...
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