In a nutshell This study investigated the effectiveness and safety of sacituzumab govitecan (Trodelvy; SG) compared to chemotherapy in patients with relapsed or refractory metastatic triple-negative breast cancer (mTNBC). The data showed that SG significantly improved the survival outcomes of these patients compared to chemotherapy. Some background...
Read More
In a nutshell This study evaluated the effects and outcomes of adding everolimus (EVE; Afinitor) plus letrozole (LET; Femara) to hormonal therapy for the treatment of premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (BC). The data showed that the combination of EVE+LET improved survival...
Read More
In a nutshell This study evaluated the effectiveness of adding targeted therapy to chemotherapy before surgery for the treatment of patients with inflammatory breast cancer (IBC). The data showed that adding targeted therapy is more effective than chemotherapy alone for these patients. Some background IBC is a rare and aggressive form of...
Read More
In a nutshell The authors evaluated the safety and effectiveness of paclitaxel (Taxol) in combination with alisertib (MLN8237) for the treatment of advanced breast cancer (BC). The authors observed that a weekly, reduced dose of paclitaxel combined with alisertib improved the survival without cancer worsening in these...
Read More
In a nutshell This article reviewed the common side effects of estrogen deprivation during hormonal therapy for women with breast cancer and provided an update on alternative therapies to manage these symptoms. Some background Breast cancer (BC) is one of the most common cancers affecting women worldwide. Some BC cells grow in response to female...
Read More
In a nutshell The authors investigated whether intra-operative electron radiotherapy (IOERT) boost reduces breast cancer recurrence compared to standard radiotherapy. They found that IOERT slightly reduced cancer recurrence compared to standard external beam radiotherapy (EBRT). Some background Breast cancer is the most commonly diagnosed...
Read More
In a nutshell This study compared the real-world safety and effectiveness of the palbociclib (Ibrance) plus letrozole (Femara) versus letrozole alone in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor-negative (HER2-) metastatic breast cancer (MBC). The data concluded that palbociclib in combination with...
Read More
In a nutshell This article compared the outcomes of older patients with low-risk breast cancer treated with accelerated partial breast irradiation (APBI) or ultra-APBI. The authors found that both treatment methods resulted in similar outcomes and side effects in these patients. Some background Breast cancer is the most commonly diagnosed...
Read More
In a nutshell This study investigated the effectiveness of Pilates compared with circuit-based exercise in reducing joint pain during hormone therapy for women with breast cancer. The data showed that Pilates was more effective than circuit-based exercise in reducing joint pain for these patients. Some background Many of the patients with...
Read More
In a nutshell This study is searching for participants with advanced solid tumors including breast cancer to examine the safety and effectiveness of experimental drug avapritinib (AYVAKIT). The main outcomes to be measured are the response to treatment and side effects. This trial is being conducted in Texas, US. The details Some cancers grow as a...
Read More
In a nutshell This study compared the effectiveness and safety outcomes of radiotherapy (RT) after immediate autologous breast reconstruction (IABR) following breast-conserving surgery (BCS) in patients with breast cancer. The data showed that RT following IABR provided aesthetically satisfactory results with manageable side effects in these...
Read More
In a nutshell This study compared the effectiveness and safety outcomes of current chemotherapy regimens for treatment in patients with early-stage breast cancer (BC). The data showed that the current treatment regimens have similar effectiveness. Some background BC is classified into different subtypes depending on the presence or...
Read More
