In a nutshell This study examined the association of physical activity (PA) and sedentary time (ST) with pain, fatigue, and depressive symptoms over time among survivors of breast cancer (BC). The data showed that lower ST and higher PA is associated with lower depressive symptoms in long-term survivors of BC. Some background BC is one of the most...
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Evaluating the occurrence and predictors of peripheral nerve disease after breast cancer treatment.
In a nutshell This study evaluated the occurrence and clinical predictors of peripheral neuropathy (PN; nerve damage) in long-term survivors of breast cancer (BC). The data showed that PN is an important long-term consequence of taxane-based chemotherapy in survivors of BC. Some background BC is one of the most common forms of cancer in women....
Read MoreWhich combination of treatments is better for HER2 positive advanced breast cancer?
In a nutshell This study compared two treatment regimes for HER2 positive breast cancer; pyrotinib (Irene) plus vinorelbine (Navelbine), or lapatinib (Tykerb) plus capecitabine (Xeloda). It found that pyrotinib plus vinorelbine (PV) improved survival without cancer progressing compared to lapatinib plus capecitabine (LC). Some background...
Read MoreComparing platinum-based chemotherapy and immunotherapy for the treatment of patients with early-stage triple negative breast cancer.
In a nutshell This study compared the effectiveness and safety outcomes of platinum-based chemotherapy and immune checkpoint inhibitors (ICIs) for the treatment of patients with early-stage triple-negative breast cancer (TNBC). The data showed that ICI plus chemotherapy was associated with good outcomes with reduced side effects compared with...
Read MoreTucatinib plus trastuzumab and capecitabine preserves health-related quality of life in patients with metastatic HER2-positive breast cancer.
In a nutshell This study evaluated the impact of tucatinib (Tukysa) in combination with trastuzumab (Herceptin) and capecitabine (Xeloda) on health-related quality of life (HR-QoL) in patients with metastatic human epidermal growth factor (HER2)-positive breast cancer (BC). The data showed that this combination preserved HR-QoL in these patients. Some...
Read MoreEvaluating the benefits of denosumab on bone health in women with early-stage breast cancer.
In a nutshell This study evaluated the benefits of denosumab (Xgeva) on the bone health of women with early-stage breast cancer (BC). The data showed that denosumab improved bone-related outcomes in women with high-risk early-stage BC Some background BC is one of the most common forms of cancer in women. Early-stage BC is used to describe BC that is...
Read MoreEvaluating eribulin versus other treatment options in women with advanced breast cancer.
In a nutshell This study compared the safety and effectiveness between eribulin (Halaven) and non-eribulin-based chemotherapy regimens in patients with advanced breast cancer (BC). The data showed that eribulin significantly improved survival outcomes with manageable side effects in these patients. Some background Advanced BC has spread...
Read MoreEvaluating the effects of adding chemotherapy to trastuzumab treatment on mental functioning in older patients with HER2-positive breast cancer.
In a nutshell This study investigated the effects of adding chemotherapy to trastuzumab (Herceptin) treatment on cognitive (thinking and reasoning) functioning in older patients with HER2-positive (HER2+) breast cancer (BC). The data showed that the addition of chemotherapy did not impact cognitive functioning in these women. Some...
Read MoreDoes lumpectomy followed by radiation improve survival outcomes in HER2 positive and triple-negative breast cancer with high tumor-infiltrating lymphocytes?
In a nutshell This study evaluated the survival outcomes after lumpectomy followed by radiation versus mastectomy alone in patients with early-stage HER2-positive (HER2+) breast cancer (BC) and triple-negative breast cancer (TNBC) with low or high tumor-infiltrating lymphocytes (TILs). The data showed that lumpectomy followed by radiation improves...
Read MoreEvaluating the frequency and outcomes of contralateral axillary metastasis in patients with inflammatory breast cancer.
In a nutshell This study investigated the frequency and outcomes of contralateral axillary metastasis (CAM) in patients with inflammatory breast cancer (IBC). The data showed that CAM was common at diagnosis in patients with IBC and was best identified by ultrasound and positron emission tomography (PET). Some background IBC is a rare and aggressive...
Read MoreSearching for patients with unresponsive breast cancer to trial an experimental treatment.
In a nutshell This trial aims to assess the safety and effectiveness of an experimental drug, CYT-0851 in the treatment of B-cell and solid tumors, including breast cancer, that have come back or are no longer responsive to treatments. The main outcomes to be measured are the side effects and the overall response to the treatment....
Read MoreComparing the recurrence rates of breast cancer after immediate or delayed breast reconstruction.
In a nutshell This study evaluated the rates of local, regional, and distant recurrence between patients who received immediate or delayed autologous deep inferior epigastric perforators (DIEP) flap breast reconstruction (BR). The data showed that there is an increased risk for breast cancer (BC) recurrence in women who received a delayed BR...
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