In a nutshell This report summarized important updates that have been made to the National Comprehensive Cancer Network’s guidelines for the use of systemic therapy in the treatment of breast cancer. Some background The National Comprehensive Cancer Network (NCCN) is a group of 26 of the world's leading cancer centers that...
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In a nutshell The authors aimed to assess and compare a number of surgical procedures used to treat and limit the risk of developing breast cancer. The study showed that there was no significant difference between contralateral prophylactic mastectomy (CPM) and breast-conserving treatment (BCT) on survival from breast cancer. Some background...
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In a nutshell This study looked at the effectiveness of a new granisetron (Sustol) formulation for the treatment of nausea and vomiting during breast cancer treatment. The study concluded that the new formulation effectively prevented nausea and vomiting over 4 chemotherapy cycles in breast cancer patients. Some background A known side effect of...
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In a nutshell This analysis provides recommendations on the correct use of biomarkers to guide decisions on systemic therapy for metastatic breast cancer. The article concluded that it is important that the medical community continue to carry out high-quality biomarker research for women with advanced breast cancer. Some background To help doctors...
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In a nutshell This study investigated the effects of the drug denosumab (Prolia) in postmenopausal patients with hormone-receptor positive breast cancer treated with aromatase inhibitors. The study concluded that denosumab reduces the risk of bone fracture in these patients. Some background Aromatase inhibitors are hormonal therapies....
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In a nutshell The authors aimed to determine if palbociclib (Ibrance) could help treat women with metastatic (spread to other areas of the body) breast cancer. The researchers concluded that palbociclib showed good response rates from women with metastatic breast cancer whose cells expressed a protein called retinoblastoma (Rb). Some background...
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In a nutshell This analysis examined the risk factors and occurrence of severe fatigue following breast cancer treatment. The authors concluded that approximately one in four breast cancer survivors suffers from severe fatigue. Some background Fatigue is a common side effect of breast cancer treatment. Symptoms of fatigue can include lack of...
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In a nutshell This study aimed to determine the effectiveness of goserelin (Zoladex) treatment with chemotherapy in young breast cancer patients. The study concluded that goserelin treatment with chemotherapy improved pathological complete response (pCR) rates. Some background A long-term and potentially devastating effect of chemotherapy...
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In a nutshell This study investigated predictors of response to therapy in patients with HER2-positive advanced breast cancer. The study concluded that mucocutaneous toxicities (those affecting the skin or mucous membranes) could be predictors of the response to lapatinib (Tykerb or Tyverb) in patients with HER2-positive advanced breast...
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In a nutshell The authors aimed to determine whether the use of beta-blockers could reduce the risk of cancer recurrence (the cancer comes back) in women with breast cancer. This study showed that beta-blockers can reduce the risk of cancer recurrence and the risk of death due to cancer. Some background Beta-blockers are a class of drug that are...
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In a nutshell The authors aimed to assess the influence of possible infections following breast reconstruction on the risks of breast cancer recurrence. This study showed that post-operative complications or infections had a significant impact on the rates of breast cancer recurrence. Some background Breast reconstruction surgery is a procedure...
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In a nutshell This study investigated the impact of resistance training on markers of inflammation in breast cancer survivors. The study concluded that resistance training might be beneficial in improving inflammation in breast cancer survivors. Some background Inflammation is a normal part of the immune system response to an invader, such as...
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