In a nutshell This phase 2 trial will evaluate the safety and effectiveness of ribociclib (Kisqali) combined with hormonal therapy in patients with estrogen receptor-positive (ER+) breast cancer (BC). The main outcome will be the number of patients that complete 1 year of treatment and survival without signs of cancer. The trial will...
Read MoreIn a nutshell This phase 2 trial will investigate the safety of pembrolizumab (Keytruda) in combination with VRP-HER2 vaccination in HER2-positive breast cancer (BC). The main outcomes will be the response of the immune system, clinical response, and side effects. This trial will be taking place in North Carolina, the U.S. The...
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In a nutshell This study investigated the benefit of anthracyclines (ATCs) in early breast cancer. They found that this treatment was an effective treatment in patients with early breast cancer. Some background Breast cancer (BC) is one of the most common cancers. Early BC is usually treated with surgery to remove the tumor....
Read MoreIn a nutshell This study investigated if trastuzumab (Herceptin)/paclitaxel (Taxol) reduces the risk of local-regional recurrence (LRR) in patients with HER2-positive breast cancer (BC). They found that this treatment reduced LRR risk in HER2-positive patients. Some background Breast cancer (BC) is one of the most common cancers....
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In a nutshell This study wanted to find out if adding the medication denosumab (Prolia, Xgeva) to cancer treatment for women with breast cancer reduces the risk of bone fractures. The study found that the patients treated with denosumab survived better, but there was no significant difference in the number of bone fractures. Some background Breast...
Read MoreIn a nutshell This study evaluated the side effects associated with intensity-modulated radiation therapy (IMRT) for advanced breast cancer. This study found that most side effects were mild and did not lower quality of life for patients. Some background Radiotherapy is often performed in breast cancer patients after surgery. Previous studies have...
Read MoreIn a nutshell This study investigated chemotherapy regimens in early breast cancer (BC). They found that shortening the duration of treatment improved BC outcomes. Some background Breast cancer (BC) is one of the most common cancers. Standard treatment involves chemotherapy. Standard chemotherapy involves taking a combination of...
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In a nutshell This phase 2 trial will investigate the safety of durvalumab (Imfinzi) in combination with standard hormonal treatment for breast cancer (BC). The main outcome will be the response to treatment. The trial is recruiting in Tampa, Florida, US. The details Breast cancer (BC) is one of the most common cancers. It affects bothe...
Read MoreIn a nutshell This study will examine how safe and effective the medication atezolizumab (Tecentriq) is in combination with other anti-cancer medicines for treating early stage HER2+ breast cancer. The main outcome that will be measured is how many patients completely respond to treatment, with no trace of the cancer remaining. The details...
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In a nutshell This study investigated whether endocrine therapy affects memory in older women with breast cancer. This study concluded that endocrine therapy had a negative effect on these patients' memory, especially on verbal memory (memory related to words). Some background Some types of breast cancer can be treated using endocrine...
Read MoreIn a nutshell This phase 3 trial will investigate the safety and effectiveness of adagloxad simolenin (AGS)/OBI-821 in triple-negative breast cancer (TNBC). The main outcome will be a change in survival without invasive disease. The details Breast cancer (BC) is one of the most common cancers. BC treatment depends on the tumor type....
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New: Thanks to InVideo, we have a video version of the post below. Check it out at bottom of the post. Incredible immunotherapy responses in some cancers, but not in others, have puzzled the research community. What is it about some cancers that allows the immune system to be activated? Why are some cancers able to evade the immune system even when...
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