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stroke | Research | 10 pages | source: Medicine | Added Oct 25, 2021

Is home-based rehabilitation as effective as a hospital-based programme for stroke patients?

This study compared home-based rehabilitation with hospital-based rehabilitation after a stroke. It found that both programs improved balance and walking in these patients. 

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rheumatoid arthritis | Research | Treatment | 10 pages | source: Clinical and experimental rheumatology | Added Oct 24, 2021

Is long-term treatment with abatacept plus methotrexate safe and effective for rheumatoid arthritis patients?

This study assessed the long-term safety and efficacy of abatacept (Orencia) plus methotrexate (Rheumatrex, Trexall) in patients with rheumatoid arthritis who have not responsed to methotrexate alone.

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lung cancer | Research | 5 pages | source: PLOS ONE | Added Oct 24, 2021

Angiopoietin-2 mRNA as a new prognostic factor for lung cancer

This article investigated the potential of angiopoietin-2 (Ang-2) mRNA as a new cancer progression marker.

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diabetes mellitus | Research | 10 pages | source: Diabetes Care | Added Oct 23, 2021

Exercise: improving control of blood glucose levels and reducing cardiovascular disease risk in type 1 diabetics

This study examined whether exercise is beneficial in improving control of blood glucose levels and reducing the risk of cardiovascular disease in type 1 diabetics.  

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kidney stones | Expertise | 0 pages | source: NutritionFacts.org | Added Oct 23, 2021

How to Treat Kidney Stones with Diet

Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the above video.

Studies suggest that excessive animal protein consumption poses a risk of kidney stone formation, likely due to the acid load provided by the high content of sulfur-containing amino acids in animal protein, as I explored in my video on preventing kidney stones with diet. But what about treating kidney stones? Most stones are calcium oxalate–formed like rock candy when the urine becomes supersaturated–so doctors just assumed if they’re made out of calcium, we just have to tell people to reduce their calcium intake. So that was like the dietary gospel for kidney stone sufferers until this study was published in the New England Journal of Medicine, pitting the two diets against one another—low calcium versus low animal protein and salt. And it was the restriction of animal protein and salt that provided greater protection: cutting the risk of having another kidney stone within five years in half.

What about cutting down on oxalates, which are concentrated in certain vegetables? A recent study found there was no increased risk of stone formation with higher vegetable intake. In fact, greater dietary intake of whole plant foods, fruits, and vegetables were each associated with a reduced risk independent of other known risk factors for kidney stones–meaning one may get additional benefits bulking up on plant foods, in addition to just restricting animal foods.

The reason a reduction in animal protein helps is not only because it reduces the production of acids within the body. A reduction in animal protein should also limit the excretion of urate–uric acid crystals that can act as a seed to form calcium stones, or can create entire stones themselves. Uric acid stones are the second most common kidney stones after calcium. There are two ways to reduce uric acid levels in the urine: a reduction in animal protein ingestion, or drugs. And removing all meat can remove 93% of uric acid crystallization risk. Here’s the risk of crystals forming eating the standard Western diet for five days. And then, switching to a vegetarian diet leads to a 93% drop in risk within days.

To minimize uric acid crystallization, the goal is to get the urine pH up to ideally as high as 6.8, so a number of alkalinizing chemicals have been developed. But we can naturally alkalize our urine up to the recommended 6.8 using purely dietary means; namely, by removing all meat, which takes someone eating the standard Western diet up from an acid 5.95 right up to the target of 6.8 eating a vegetarian diet. You can inexpensively test your own diet with a little bathroom chemistry, for not all plant foods are alkalinizing and not all animal foods are equally acidifying.

A so-called LAKE score was developed, a Load of Acid to Kidney score, which takes into account both the acid load of foods and their typical serving sizes, and can be used to help people modify their diet for the prevention of both uric acid and calcium kidney stones and other diseases. This is what they found. The single most acid-producing food was fish, like tuna. Then pork, then poultry, then cheese, though milk and other dairy only rate down here; then comes beef. Eggs are actually more acidic than beef, but people tend to eat less eggs at a sitting, so they come in here. Some grains can be a little acid-forming, such as bread, rice; but not pasta, interestingly. Beans are significantly alkaline-forming, but not as much as fruits, and vegetables, the most alkaline-forming of all foods.

Through dietary changes alone, we may be able to dissolve uric acid stones away completely–cure them. Now you see it, now you don’t. No drugs, no surgery, just telling them to drink more water and modify their diet, such as restricting the intake of animal protein, and the kidney stone was gone.

To summarize, here are the five types of kidney stones. And the most important things we can do diet-wise are to drink 10 to 12 cups of water a day, and reduce animal protein, reduce salt, eat more vegetables, and more vegetarian.

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hypertension | Research | Treatment | 10 pages | source: The New England Journal of Medicine | Added Oct 22, 2021

Examining treatment options to reduce blood pressure in patients with obstructive sleep apnea

This study examined the effects of continuous positive airway pressure (CPAP) treatment and supplemental oxygen on blood pressure in patients with obstructive sleep apnea. The authors concluded that treatment with CPAP but not supplemental oxygen was associated with a significant reduction in blood pressure. 

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rheumatoid arthritis | Research | 22 pages | source: Arthritis Care & Research | Added Oct 21, 2021

Use of methotrexate in daily practice in the United States

The authors examined the patterns of use of methotrexate: dose administered, method of administration, and duration of treatment. 

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diabetes mellitus | Research | Treatment | 7 pages | source: PLOS ONE | Added Oct 21, 2021

Addition of insulin glargine to combination therapy with oral anti-diabetic drugs: a promising therapeutic option for type 2 diabetes

This study compared the effects of adding insulin glargine treatment  to metformin (Glucophage), glimepiride (Amaryl) or their combination in patients with uncontrolled type 2 diabetes mellitus.

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hypertension | Research | 10 pages | source: American journal of hypertension | Added Oct 20, 2021

Risk factors for myocardial ischemia in patients with resistant hypertension

The aim of this study was to identify risk factors for myocardial ischemia (reduced blood flow to the heart) in patients with resistant hypertension. The authors identified a number of risk factors that increase the likelihood of myocardial ischemia in patients with resistant hypertension.

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rheumatoid arthritis | Research | Treatment | 8 pages | source: Arthritis Care & Research | Added Oct 19, 2021

Does a loss in hand bone mineral density increase risk of future bone erosion?

This paper studies whether a loss of hand bone mineral density (BMD, the amount of calcium and other minerals in an area of bone) in the first 6 months of treatment increases the risk of bone erosions at 12 months for patients with rheumatoid arthritis.

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