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erectile dysfunction



Source: Cochrane database of systematic reviews

  • Published: Aug 17, 2004
  • Added to your feed: Sep 04, 2019
  • Added by Medivizor: Nov 22, 2015
  • Updated by Medivizor: Nov 22, 2015
  • Prostaglandin E1 and sexual function

    In a nutshell

    This review analyzed the effectiveness and safety of prostaglandin E1 in the treatment of erectile dysfunction.

    Some background

    Erectile dysfunction (ED) is one of the most common medical problems among men. ED may have a dramatic impact on the quality of life of men and their partners.

    Prostaglandin E1 (PGE1) is a naturally occurring hormone which causes dilation (widening) of blood vessels. PGE1 is commonly used to treat ED. Men either inject PGE1 into their penis, or insert a small pellet containing the drug into the opening at the end of the penis (into the urethra).

    Methods & findings

    The current review examined the safety and effectiveness of PGE1 in ED. Four trials, including a total of 1873 men with ED, were included in this analysis.

    Men using PGE1 were seven times more likely to have at least one successful intercourse compared to untreated men or men receiving a placebo (a substance with no effect on the body). One study reported at least one successful intercourse among 63.6% of men receiving PGE1. In another study, 55.5% of men receiving PGE1 reported a “good” or “excellent” response to treatment.

    The most common adverse effects reported were penile pain and minor urethra injury. Adverse effects were found to occur more often and intensely as the dose of PGE1 increased. In one of the studies reviewed, penile pain was reported among 9% of men receiving 125 mcg of PGE1, and in 18% of men receiving 1000 mcg of PGE1.

    The bottom line

    The researchers concluded that PGE1 is a safe and effective treatment for erectile dysfunction, and that PGE1 resulted in a high percentage of men achieving satisfactory sexual intercourse.

    What's next?

    Consult with your physician regarding prostaglandin E1 for the treatment of erectile dysfunction.

    This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided by Medivizor solely at your own risk. Medivizor makes no warranties or representations as to the accuracy of information provided herein. If you have any concerns about your health, please consult a physician.

    Discussion about this item

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    1. John Jun 12, 2023

      PGE1-a pellet inserted into the penis sounds better than a needle in your penis Ouch!
      How far do you push the pellet in I wonder- Reply

    2. Michael Jun 14, 2023

      From what I understand, the medicine comes in a pellet. You're supposed to empty your bladder first so the opening will be wet and insertion easier. It comes with a device you place the pellet in. You put the device tip into your urethral opening just at the tip, not jamming it in, and you press the button. The medicine needs time to work (about 5 minutes) and you need to massage the head of the penis to get the medicine going. (I remember a product called MUSE that preceded PEG-1. Maybe the instructions are similar, or maybe everything has changed. I also hear that the shots don't hurt much, either. The needle is super-fine. Reply

    3. Edward Jun 15, 2023

      I've tried the shot & it worked but killed the moment.
      The medicine is expensive & losses strong in a few weeks Reply

    4. Anonymous Jun 15, 2023

      When done right the injections do not hurt Reply

    5. Anonymous Jun 26, 2023

      I used both TriMix and BiMix both caused pain near the head of my penis resulting in not feeling sexual urge and loss of what was a nearly immediate erection. Very disheartening after mostly overcoming the anxiety of giving myself the shot. Reply

    6. Anonymous Jun 27, 2023

      Were you injecting on the base of your penis? It does take time to get experienced with it. Now I have little more than a brief one second pinch when I inject. No pain in the head of the penis. I use Americare Compounding in Garden City Long Island. They will work with you to resolve the issues you experienced. Very professional and much cheaper than Boston Medical/ Clinic For Him. Reply


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