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prostate cancer

Research

Lifestyle

Source: Cancer

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  • Published: May 19, 2014
  • Added to your feed: May 24, 2018
  • Added by Medivizor: May 30, 2016
  • Updated by Medivizor: May 30, 2016
  • The risk of different types of second cancers in prostate cancer survivors

    In a nutshell

    This study examined the risk of different types of second cancers in prostate cancer survivors. Researchers reported a reduced risk of various second cancers among men with prostate cancer compared to the cancer incidence in the general population.

    Some background

    Advances in treatment and early detection of prostate cancer have increased survival and led to a growing number of men living with prostate cancer. The increased life expectancy of prostate cancer survivors exposes them to the possibility of later developing second cancers. Previous studies have estimated that about 16% of prostate cancer survivors are later affected by second cancers. How the risk of different types of second cancers compares to the general population has not been fully studied.

    Methods & findings

    The aim of this study was to compare the risk of second cancers in men with prostate cancer, relative to the general population.

    The records of 441,504 men with prostate cancer were analyzed. Prostate cancer was the first cancer diagnosis in all men included. Most men were aged between 65 and 74 years at the time of prostate cancer diagnosis. The incidence of second cancers was compared to the cancer rate of the general population. The diagnosis of a second cancer must have occurred at least 2 months after the prostate cancer diagnosis.

    10% of men with prostate cancer later developed a second cancer. Compared with cancer incidence in the general population, men with prostate cancer had a lower overall risk of second cancers (about 40% lower). The risk was significantly reduced for a number of different second cancers. These included leukemia, oral cancers (including mouth, nasal, and esophagus cancer), respiratory cancers (lung, bronchus, and larynx), as well as cancers of the stomach, colon, rectum, liver, gallbladder, and pancreas. The reduced risk of these cancers was less pronounced for men who previously received radiation for prostate cancer.

    Significant increases in the risk of cancers of the soft tissue, heart, bladder, kidney, and of the endocrine (metabolism) system were observed among men with prostate cancer. In the 2 to 11 months after prostate cancer diagnosis, men with prostate cancer were at increased risk of lymphoma, as well as bladder, kidney, thyroid, and endocrine system cancers. This risk then significantly decreased from 120 months after diagnosis.

    Men with early-onset prostate cancer had a higher risk for bladder and thyroid cancer compared to the general population and compared to men with late-onset prostate cancer. The risk of a second cancer of the stomach, colon, bladder, kidney, and of leukemia was higher for black men with prostate compared to caucasian men with prostate cancer.

     

    The bottom line

    Researchers concluded that men with prostate cancer had a lower risk for various second cancers compared to the cancer incidence in the general population, but at a higher risk for others. Previous radiation, age at diagnosis and ethnicity affected long-term risk of second cancers.

    Disclaimer:
    This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided by Medivizor solely at your own risk. Medivizor makes no warranties or representations as to the accuracy of information provided herein. If you have any concerns about your health, please consult a physician.

    Discussion about this item

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    1. Larry May 30, 2016

      "Heart Cancer"? Never heard of it? Reply

      • Kim@Medivizor May 31, 2016

        Hi Larry, there are types of tumors that can develop in the heart. Sarcomas, for example are a type of cancer that develop in the soft tissues of the body, like the heart. Reply

        • Mike Jun 01, 2016

          Okay, still never heard of either. What are the symptoms? Do they appear to be a heart attack? Reply

    2. Larry Jun 01, 2016

      Interesting...never noted it showing up in any statistics...I'm assuming it is quite rare? Reply

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