This study evaluated the effects of carbohydrate-restricted diets and intermittent fasting (IF) in patients with obesity, type 2 diabetes (T2D), and hypertension (high blood pressure). The authors recommended that in adults with T2D, overweight or obesity, a moderately-low carbohydrate diet can be considered as a dietary regimen for blood sugar control and weight reduction. 

This study investigated the safety and effectiveness of different doses of asundexian (BAY 2433334) in patients with acute myocardial infarction (MI; heart attack) treated with dual antiplatelet therapy (DAPT). The data showed that asundexian 50 mg when added to DAPT inhibits blood clotting factor XIa by more than 90% without significantly increasing the risk of bleeding in these patients.

This study evaluated the effectiveness of chemotherapy given before surgery (neoadjuvant chemotherapy; NAC) for the treatment of patients with colorectal cancer liver metastasis (CRLM) at high risk. The data showed that NAC improved the overall survival of these patients.

This review assessed the effect of vitamin B12 supplementation on clinical outcomes when used alone or combined with other treatments for diabetic peripheral neuropathy (PN). The authors concluded that a greater reduction of PN symptoms occurred with the use of B12 supplementation alone or in combination with other treatments compared to placebo.

This study evaluated the effectiveness and safety of high-dose rosuvastatin (Crestor) combined with telmisartan (Micardis) or amlodipine (Norvasc) on glucose metabolism in patients with atherosclerotic cardiovascular disease (ASCVD), hypertension (high blood pressure), and impaired fasting glucose (IFG or prediabetes). The data showed that telmisartan significantly reduced the fasting glucose levels to normal glucose levels and prevented the new onset of diabetes in these patients.

This study compared the long-term outcomes of percutaneous coronary intervention (PCI) using everolimus (Afinitor)-eluting stents (Xience) versus coronary artery bypass grafting (CABG) in patients with multivessel coronary artery disease (CAD). The data showed that both treatments were associated with a similar risk of heart attack, stroke, and death over the long term in these patients. However, PCI increased spontaneous heart attacks and repeat revascularization compared to CABG in these patients.

The study evaluated the effectiveness of massage therapy for chemotherapy-induced peripheral neuropathy (CPIN) in patients with breast and gastrointestinal (GI) cancer. The main finding of the study was that intensive massage therapy 3 times a week showed promising results in these patients. 

This study compared the safety and effectiveness of different doses of an oral insulin capsule formulation (Capsulin™) to patients with early-stage type 2 diabetes (T2D). The data showed that twice-daily, orally administered Capsulin at a dose of 150 international units (IU) was safe and resulted in a significant lowering of glycated hemoglobin (HbA1c; blood glucose control over the past 2-3 months), fasting plasma glucose (FPG) and triglycerides (TG; blood fats) levels.

This study evaluated the effectiveness and safety of a shorter dual antiplatelet therapy (DAPT) duration after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) in patients with acute or recent myocardial infarction (MI; heart attack) at high bleeding risk. The data showed that a shorter DAPT duration (1 month) significantly reduced the risk of bleeding compared with a long DAPT duration (minimum of 3 months) with similar risks of death or heart attacks in these patients.

The study evaluated the effectiveness and safety of radium-223 dichloride (Xofigo) treatment in real-world patients with metastatic castration-resistant prostate cancer (mCRPC). The data showed that radium-223 dichloride treatment was well tolerated and reduced pain in real-world patients with mCRPC spread to the bone.