This randomized study examines the safety and effects of COGNUTRIN therapy on cognitive performance in breast cancer survivors following chemotherapy.

This phase II trial (a trial designed to evaluate effectiveness and safety) aims to evaluate the effectiveness of tetrathiomolybdate in management of patients with moderate- to high-risk breast cancer. The outcome to be investigated is time until the disease progresses. 

This study will evaluate whether adrenocorticotropic hormone (ACTH) gel can decrease disease symptoms in patients with rheumatoid arthritis that is uncontrolled by other medications. The success of this treatment will be measured by changes in disease activity (number of affected joints) after 12 weeks of treatment. This study is being conducted in Pittsburgh, Pennsylvania.

Breast cancer is a type of cancer originating from breast tissue, most commonly from the milk ducts or the milk-producing glands (lobules). Cancers originating from ducts are known as ductal carcinomas, while those originating from lobules are known as lobular carcinomas. Breast cancer may also (rarely) arise from the tissue surrounding the ducts and lobules (stroma).

Rheumatoid arthritis (RA) is an inflammatory disease affecting the joints, the connections between bones. Unlike the more common osteoarthritis, which is due to wear and tear on the joints, RA is an autoimmune disorder, which occur when the immune system, the body’s defense against infection, starts attacking healthy tissue.