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rheumatoid arthritis | Research | 27 pages | source: Arthritis Care & Research | Added Jan 24, 2016

Can exercise improve mood in tired patients? The benefits of exercise for arthritis patients

This study examined the effects of exercise on mood when arthritis patients experience fatigue.

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breast cancer | Clinical Trial | Added Jan 22, 2016

Looking for women who are due to undergo mastectomy to test the effectiveness of acupuncture for pain relief after surgery.

This clinical trial in Minnesota aims to test the effectiveness of acupuncture after mastectomy surgery. The primary outcome measures will be the level of pain, nausea, anxiety and ability to cope after surgery.

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breast cancer | Research | 8 pages | source: Cancer Treatment Reviews | Added Jan 21, 2016

Cannabinoids: Preclinical hope for breast cancer therapy

Could cannabis also be a cure?

 

This review explored the use of cannabinoids in the treatment of breast cancer.

 

Medical cannabis, as well as multiple cannabinoid-based drugs, have long been used to treat cancer symptoms, such as cancer-related pain and the nausea and vomiting associated with chemotherapy. Cannabinoids are known to be safe and well-tolerated among cancer patients, and patients receiving medical cannabis often report significant improvements in quality of life.

Recently, research has begun to explore the use of cannabinoids as a possible treatment for breast cancer rather than simply a symptomatic therapy. The current review analyzed recent research investigating cannabinoids as a possible therapy for different types of breast cancer.

 

This review focused on pre-clinical research, investigating tumor cells taken from breast cancer patients or animal models. No clinical trials involving human breast cancer patients were reviewed.
Overall, cannabinoids have been shown to block cancer cell proliferation and reduce cancer cell migration in all breast cancer subtypes.

THC (tetrahydrocannabinol), the most commonly investigated cannabinoid, has been found to reduce both the rate of tumor growth and the overall number of developing tumors in HER2-positive breast cancer through the reduction of cell proliferation and by increasing cancer-cell death.  Some studies have also shown cannabinoids to decrease the formation of blood vessels within the tumor, which inhibits cancer growth.

The cannabinoid receptor type 2 (CB2) receptor (a complex found on the surface of cells) has been identified as the receptor responsible for many of the beneficial effects of cannabinoids. High amounts of CB2-receptors have been found to be more commonly associated with HER2-positive or triple-negative breast cancer cells. In models investigating triple-negative breast cancer, stimulation of the CB2-receptor with a cannabinoid-based drug,  JWH-133, lead to a significant decrease in the number of proliferating cancer cells, as well as blood vessel growth within the tumor.

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breast cancer | Research | Treatment | 10 pages | source: PLOS ONE | Added Jan 19, 2016

Who could benefit from post-mastectomy radiotherapy?

This study investigated the risk factors for recurrence in breast cancer patients treated with mastectomy without radiation therapy. The study concluded that by using these risk factors, a subgroup of patients could be defined as being at a high risk for recurrence and most likely to benefit from post-mastectomy radiotherapy (PMRT).

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rheumatoid arthritis | Research | Treatment | 8 pages | source: Annals of the rheumatic diseases | Added Jan 17, 2016

Sardines and supplements: fish oils help treat early rheumatoid arthritis

This study examined the effects of high-dose fish oil in the treatment of early rheumatoid arthritis.

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breast cancer | Research | 9 pages | source: Archives of Gynecology and Obstetrics | Added Jan 13, 2016

Breast cancer recurrence; is breast conserving therapy still relevant?

This paper studied locoregional recurrences (return of cancer to the same area) in breast cancer. They compared mastectomy (removal of entire breast) to breast conserving therapy (removal of some breast tissue). 

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rheumatoid arthritis | Research | 10 pages | source: PLOS ONE | Added Jan 12, 2016

Does rheumatoid arthritis increase the risk of kidney disease?

This study assessed the risks of rheumatoid arthritis (RA) patients developing chronic kidney disease (CKD) and glomerulonephritis (GN), and subsequently developing cardiovascular (CV) complications. The study concluded that there was an increased risk of CKD and GN in RA patients, and an increased risk of CV complications in patients with RA and CKD.

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rheumatoid arthritis | Research | Treatment | 86 pages | source: Cochrane database of systematic reviews | Added Jan 10, 2016

The benefits of rituximab for the treatment of rheumatoid arthritis

This article examined the benefits and risks of using rituximab (Rituxan, MabThera) for the treatment of rheumatoid arthritis.

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breast cancer | Research | 8 pages | source: Annals of Surgical Oncology | Added Jan 09, 2016

Do elderly breast cancer patients follow standard care in early breast cancer?

This paper studied whether elderly patients with breast cancer would have worse survival if they did not follow standard care of treatment. 

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rheumatoid arthritis | Research | Treatment | 10 pages | source: Annals of the rheumatic diseases | Added Jan 07, 2016

Is peficitinib effective and safe in the treatment of rheumatoid arthritis?

This study examined the effectiveness of peficitinib in patients with moderate to severe rheumatoid arthritis. The results showed that this new drug was safe and effective.

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