This review aimed to assess the strength of previous evidence and to better understand the current role of SARS-CoV-2 vaccination in patients with chronic lymphocytic leukemia (CLL). 

This review concluded that there is an overall lower seroconversion rate for SARS-CoV-2 vaccination in these patients as compared with the general population. This review also concluded that CLL treatment worsened the defective response to vaccination observed in these patients.

This study compared the safety and effectiveness of whole-pelvis radiotherapy (WPRT) and prostate-only radiotherapy (PORT) in patients with node-positive prostate cancer (PC) (PC that has spread to nearby lymph nodes). The study found that WPRT improves survival without relapse in these patients, with more short-term gastrointestinal side effects.

This study investigated the effects of foot-ankle therapeutic exercises on daily physical activity and gait (walking) speed in people with diabetic peripheral neuropathy (DPN). The data showed that at 12 weeks, these exercises led to improvements in fast walking speeds and quality of life compared to usual care.

This study analyzed the safety and effectiveness of dapagliflozin (Farxiga) in patients with type 2 diabetes (T2D) across different ranges of baseline systolic blood pressure (SBP; blood pressure when the heart beats). The data suggested that dapagliflozin reduced the risk of hospitalization for heart failure (HHF) and kidney-related outcomes and was safe for use across different levels of SBP without causing an increase in short-term (acute) kidney injury, dehydration, or amputations in patients.

This study compared the effectiveness and safety of an early and a delayed invasive strategy (IS) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). The data showed that there were no significant differences in the risk of death, heart attacks, stroke rates, major bleeding, or revascularization between early and delayed IS. Early IS significantly reduced the risk of recurrent ischemia and length of hospital stay in these patients.

This study evaluated the effectiveness and safety of low-intensity extracorporeal shock wave therapy (Li-ESWT) for patients with diabetes and erectile dysfunction (ED). The data showed that Li-ESWT was safe and effective in improving the symptoms of ED in these patients.

This study compared the effectiveness and safety of immune checkpoint inhibitors (ICIs) between randomized and real-world studies in patients with advanced non-small cell lung cancer (NSCLC) or melanoma. The data showed that ICIs were similarly effective and safe in both randomized and real-world studies for these patients.

This study evaluated the effectiveness and safety of adding short-term androgen deprivation therapy (ADT) with or without pelvic lymph node radiotherapy (PLNRT) to prostate bed salvage radiotherapy (PBRT) after surgery in patients with prostate cancer (PC). The study found that adding short-term ADT and PLNRT to PBRT significantly improved the survival outcomes without cancer progression in these patients.

This study evaluated the effectiveness of different first-line treatments in elderly and non-elderly patients with advanced epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). The data showed that osimertinib (Tagrisso) was the best treatment regimen to improve survival without cancer worsening in elderly patients. At the same time, the standard of care plus chemotherapy was the best strategy to improve survival without cancer worsening for younger patients.

This study compared the effectiveness and safety of short-term versus long-term dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) in patients at high bleeding risk. The data showed that short-term DAPT significantly reduced the risk of bleeding compared with long-term DAPT without an increase in the risk of death or heart attacks in these patients.