This phase 2 trial is examining the effectiveness and safety of durvalumab (Imfinzi) in the treatment of advanced rectal cancer that is not prone to genetic abnormalities. The main outcomes to be measured will be tumor response to the treatment and side effects. This trial is being conducted in the US.

This study compared the effectiveness of two different types of radiation therapy to treat rectal cancer. Researchers suggested that high-dose endorectal brachytherapy (HDEB) is associated with improved tumor response.

This trial is examining the safety and effectiveness of combination therapy with pembrolizumab (Keytruda) and lenvatinib (Lenvima) for advanced or unresponsive colorectal cancer (CRC) and other solid tumors. 

The main outcome to be measured will be the objective response rate (ORR; the percentage of participants who have complete disappearance of tumors) after 2 years.

This study investigated if high-dose vitamin D combined with chemotherapy improves outcomes in patients with metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that high-dose vitamin D was associated with an improved chance of survival.

This study investigated the effectiveness of stereotactic body radiotherapy (SBRT) in metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that SBRT is associated with improved tumor response and manageable side effects.

This trial is examining the effectiveness and safety of a combined treatment with pembrolizumab (Keytruda) and binimetinib (Mektovi). The main outcome to be measured is the tumor response to the treatment. This trial is recruiting in the United States and Canada.

This study investigated the short- and long-term outcomes of totally robotic and robotic-assisted colon surgery in the treatment of colon cancer. Researchers suggested that totally robotic surgery is a safe and effective treatment option for these patients.

This phase 1/2 trial is examining the effectiveness of durvalumab (Imfinzi) and monalizumab to treat patients with colorectal cancer or other solid tumors. The main outcomes to be measured are tumor response to the treatment and side effects.

This trial is examining the effectiveness and toxicity of PolyPEPI1018 vaccine in the treatment of advanced colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will be conducted in Italy, and Minnesota, US.

This trial is examining the effectiveness and safety of treatment with nivolumab (Opdivo) and relatlimab in patients with advanced colorectal cancer. The main outcome to be measured will be tumor response to the treatment. This trial is being conducted in Maryland, US.