This study evaluated the effectiveness and safety of adding oxaliplatin (Eloxatin; 3 months vs 6 months) to 6 months of fluoropyrimidine therapy such as 5-Fluorouracil (Adrucil) or capecitabine (Xeloda) as adjuvant (treatment after surgery) treatment in patients with stage II or III colon cancer. The data showed that adding 3 months of oxaliplatin to 6 months of fluoropyrimidine treatment could be considered an alternative adjuvant treatment option in patients treated with capecitabine plus oxaliplatin.

This study evaluated the effectiveness and safety of transanal (ta) versus laparoscopic (lap) total mesorectal resection (TME) for the treatment of patients with stage I-III rectal cancer (RC). The data showed that experienced surgeons can safely perform taTME in these patients.

This study evaluated the long-term effectiveness and safety of 3-month versus 6-month modified FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) or CAPOX (capecitabine and oxaliplatin) treatment after surgery in patients with stage 3 colon cancer. The data showed that 3-month modified FOLFOX/CAPOX treatment was as effective and safe as the 6-month treatment over the long term in these patients.

This study investigated the effect of total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (CRT) and planned adjuvant chemotherapy on the survival of patients with locally advanced rectal cancer (LARC). The data showed that TNT did not increase survival compared with standard CRT and planned adjuvant chemotherapy but increased the rate of complete response.

This study evaluated the impact of different durations of post-surgery chemotherapy in the treatment of locally advanced (spread to the lymph nodes) rectal cancer patients.

Researchers suggested that longer post-surgery chemotherapy for stage 3 patients was associated with lower metastasis (spread to other parts of the body) rates and longer disease-free survival.

The aim of this study was to compare health-related quality of life in healthy individuals and patients with rectal cancer.

This study examined whether radical surgery is a suitable follow-up approach to local excision if features indicating poor outcome are identified.

This study compared disease free survival (the time period between the end of treatment and until the disease returns or the patient relapses) for colon cancer patients with a history of smoking versus non-smokers.

This study examined the association between CIMP positive colorectal cancer and patient outcome.

This study reviewed therapies under development for the treatment of a rare form of colorectal cancer. It was found that the combination of 2 or more drug types may be the most effective treatment regime.