Posted by on Apr 5, 2019 in Stroke | 0 comments

In a nutshell

This trial is examining the effect of exercise training on depression and walking function in patients who had a stroke. The main outcome to be measured will be a change in depression score and walking function. This study is being conducted in South Carolina, the United States.

The details

Depression is a common complication of stroke. Current treatments for post-stroke depression are ineffective. This can negatively impact stroke rehabilitation.

The purpose of this study is to examine the effect of high-intensity resistance exercise training on depressive symptoms with post-stroke depression. This study will also investigate if post-stroke depression limits training-induced improvements in muscle function and walking. The main outcomes to be measured will be a change in depression score.

Who are they looking for?

This study is recruiting 48 patients. Patients must have had a stroke in the last 6-60 months. They must have weakness in their lower limbs and be able to walk without assistance. Patients must not be on any antidepressant medications.

Patients must not have and an enlarged heart or any have chest pain/breathlessness during normal daily activities. Patients must not have lung disease, be using oxygen, have any neurological disorders or severe visual impairment. Patients must not have a severe arthritis or have had a clot in the leg or lung in the past 6 months. Patients must not have uncontrolled diabetes or severe high blood pressure (greater than 200 systolic or 100 diastolic). Patients must not have a history of psychiatric problems or be enrolled in any other trial for rehabilitation.

How will it work

Patients will be randomly assigned to receive either high-intensity strength training or a stretching programme for 12 weeks. Depression scores will be assessed with a questionnaire on each visit. Change in walking speed will also be assessed on each visit. There will be 24 visits over 12 weeks.

Clinical trial locations

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Type:Interventional
Participants:48
Study ID:NCT03826771
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