In a nutshell The study evaluated the effectiveness and safety of Q-122, a new non-hormonal oral treatment for menopausal symptoms in women with breast cancer taking hormonal therapy. The study found that Q-122 is effective and safe in treating menopausal symptoms in these patients. Some background The treatment for hormone receptor-positive...
Read MoreIn a nutshell The study wanted to find out if taking the drug metformin (Glucophage) prevents insulin resistance and issues with the womb caused by tamoxifen (Novaldex) in women with breast cancer. The study found that metformin was able to prevent changes in the womb caused by tamoxifen, and also resulted in weight loss and lower...
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In a nutshell This study looked at the risk factors and protective factors surrounding non-alcoholic fatty liver disease in relation to tamoxifen (Novaldex) therapy for women with breast cancer. The authors found that a high BMI was a risk factor for tamoxifen related fatty liver disease, while exercise was a protective factor. Some background...
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In a nutshell The authors aimed to determine the risks of cancer recurrence (the cancer returns) between the time of hormone or endocrine therapy and the 10 years following. Some background Endocrine therapy is used as treatment against particular cancers that may grow in response to hormones natural to our body. This includes hormone...
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In a nutshell The authors aimed to assess the prognostic (treatment outlook) factors associated with breast cancer in post-menopausal women with specific tumor characteristics. Some background Lymph nodes are tiny bean shaped organs and are often the first site to which cancer will spread. This is known as lymph node involvement. Adjuvant...
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In a nutshell The authors aimed to determine if there was a link between patient age, tumor type and the spread of cancer. Some background Breast cancer metastasis is the spread of the cancer to other parts of the body; following original cancer of the breast. Age at original diagnosis and the area affected by the tumor are just two of the...
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In a nutshell This article looked at the risks of developing uterine cancer in women who have survived breast cancer. Some background Uterine cancer (cancer of the uterus, or 'womb') is the most common gynaecologic tumor in women (tumors relating to the female reproductive organs). Certain factors associated with breast cancer can become...
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In a nutshell The aim of this study was to investigate the relationship between survival outcomes and specific adverse events (AEs) in patients after menopause (postmenopausal) with breast cancer treated with hormone therapy. Some background Most breast cancers grow in response to estrogen, the main female sex hormone. Therefore, hormone therapy...
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In a nutshell This article evaluated whether a reduction in tissue density at mammography after tamoxifen treatment can predict survival in breast cancer patients. Some background Mammography uses x-rays to look at the breasts for signs of cancer. This diagnostic method is generally used for women over the age of 50. Younger patients usually have...
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In a nutshell This study evaluated whether there is any benefit from radiation therapy (RT) in women over the age of 70 with early stage breast cancer treated with lumpectomy (surgical removal of the cancerous lump) and tamoxifen. Some background Breast cancer in older patients is often fueled by estrogen, a female sex hormone. These cancer...
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In a nutshell The aim of this article was to discuss the way in which the latest results on cancer DNA research apply to early-stage breast cancer. Genome analysis is highly likely to play a growing role in the future but more clinical trials are needed. Some background Breast cancer is a disease with multiple symptoms and consequences that are...
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In a nutshell This study compared the benefits of chemotherapy according to hormone receptor status. The main findings were: In cancers without hormone receptors, the benefits of adding chemotherapy were significant; In cancers with hormone receptors, chemotherapy only offered modest improvement. Some background Some...
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