In a nutshell This study compared the effectiveness of surgery with and without chemotherapy with uracil and tegafur (Uftoral; UFT) plus leucovorin (LV; folinic acid) in patients with stage II colon cancer. This study concluded that surgery with UFT/LV chemotherapy significantly improved survival outcomes in these patients. Some...
Read MoreIn a nutshell This study investigated the safety and effectiveness of TAS-102 (trifluridine-tipiracil) with and without bevacizumab (Avastin) therapy in metastatic colorectal cancer (mCRC). Researchers suggested that this combined therapy might be a good treatment option for patients with advanced CRC. Some background Colorectal cancer is the third...
Read MoreIn a nutshell This study investigated the effects of maintenance therapy (MT) compared to intermittent therapy (IT) for patients with metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that MT might improve the treatment of these patients. Some background Colorectal cancer is the second most common cancer...
Read MoreIn a nutshell This study is searching for participants with advanced solid tumors to try a new treatment called repotrectinib (TPX-0005). The main outcomes that will be measured include side effects, the most effective dose and response. This trial is recruiting in the United States and Korea. The details Patients with different genetic mutations...
Read MoreIn a nutshell This study investigated the outcomes of patients with BRAF-positive colorectal cancer liver-metastasis (CRLM; spread to the liver) undergoing surgery. Researchers suggested that surgery is associated with improved outcomes for these patients. Some background Colorectal cancer is one of the most common cancers in the US. Around 25% of...
Read MoreIn a nutshell This phase 1b trial is examining the effectiveness and safety of cibisatamab in combination with atezolizumab (Tecentriq) after treatment with obinutuzumab (Gazyva) in patients with previously treated metastatic colorectal carcinoma (mCRC). The main outcomes to be measured will be side effects and...
Read MoreIn a nutshell This phase 2 trial will investigate the effectiveness of genetically-engineered cell treatment (GECT) in advanced cancer. The main outcome will be the response to treatment. This trial is recruiting at the National Cancer Institute, Maryland, US. The details There are limited treatment options for advanced cancer. One...
Read MoreIn a nutshell This trial is examining the safety and effectiveness of combination therapy with pembrolizumab (Keytruda) and lenvatinib (Lenvima) for advanced or unresponsive colorectal cancer (CRC) and other solid tumors. The main outcome to be measured will be the objective response rate (ORR; the percentage of participants who have complete...
Read MoreIn a nutshell This study investigated the effectiveness and safety of treatment with regorafenib (Stivarga) followed by cetuximab (Erbitux) in the treatment of advanced colorectal cancer. Researchers suggested that this treatment improves survival of these patients. Some background New treatments have become available in the past 20 years to treat...
Read MoreIn a nutshell This study investigated the outcomes of surgery to lung metastasis (LM; cancer spreads to the lungs) in patients with colorectal cancer. Researchers suggested that lung surgery increases the survival of these patients. Some background Colorectal cancer is one of the major diseases seen in the US. LM appear in 5-15% of patients and...
Read MoreIn a nutshell This study investigated the post-surgery factors that affect the use of chemotherapy after surgery in colorectal cancer patients. Researchers suggested that post-surgery complications are associated with delay or not receiving chemotherapy treatment. Some background Surgery and post-surgery chemotherapy are the standard...
Read MoreIn a nutshell This study investigated the risk factors for recurrence (when the cancer comes back) after surgery in patients with stage 2 and stage 3 colorectal cancer. Researchers suggested that high-risk patients can be identified by assessing tumor specific blood levels, tumor spread to the lymphatic system and infiltrative growth (IG; when the...
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