In a nutshell This study investigated the effectiveness and safety of radiotherapy in patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that radiotherapy could be a safe option for the treatment of these patients. Some background Colorectal cancer is the third most frequently diagnosed cancer....
Read MoreIn a nutshell This study compared the outcome of patients with colorectal or appendix cancer that had spread to the peritoneum (the lining of the abdominal cavity). Some background Peritoneal metastasis indicates that the initial cancer has spread to the peritoneum. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS/HIPEC) is...
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In a nutshell The authors evaluated the effectiveness of chemotherapy and targeted therapy for patients with initially unresectable (inoperable) colorectal liver metastases. Some background Liver resection (surgical removal of cancerous tissue from the liver) with chemotherapy is the standard procedure as well as the only curative...
Read MoreIn a nutshell The authors aimed to evaluate the association between age and survival outlook after surgery in colorectal cancer. Some background Generally, colorectal cancer is thought to affect mostly older people, with more than 90% of patients being diagnosed after age 55 years. However, despite there being a steady decline of colorectal cancer...
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In a nutshell The authors evaluated the association between cyclin D1 level, overall survival and disease-free survival in colorectal cancer patients. Some background In recent years, much attention has been focused on the involvement of cyclin D1 in tumor development and progression. Cyclin D1 is a protein that regulates the cell cycle, or the...
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In a nutshell In this study, researchers examined whether levels of a blood marker called microRNA-21 could help predict colorectal cancer (CRC) recurrences. Such information may help select which patients require more intensive follow-up after treatment. Some background MicroRNA consists of small pieces of RNA, a molecule that tells the...
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In a nutshell This study looked at the use of radiofrequency ablation (RFA) as a treatment for colorectal cancer which has spread to the lungs (pulmonary metastasis). Overall, the results showed that RFA treatment gives patients a better survival rate than the previous method of systemic chemotherapy which used to be the best treatment option for...
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In a nutshell The present study evaluated factors associated with residual or recurrent disease in patients with colorectal adenocarcinomas developed from adenomas initially treated endoscopically. Some background A colorectal adenoma is a benign (non-cancerous) abnormal growth in the inner lining of the large intestine (colon and rectum) also...
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In a nutshell This paper looks at the long term survival rates after radiofrequency ablation treatment of small metastatic liver tumors in patients with primary colorectal cancer. Some background Radiofrequency tumour ablation is a method used to treat patients whose tumors cannot be treated surgically. The method involves guiding...
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In a nutshell The aim of this study was to evaluate the safety and efficacy of microwave ablation therapy on pulmonary metastases (cancer spread to the lungs) that cannot be removed surgically. The study showed that it can be an effective treatment method with a success rate depending on the tumor size. Some background Pulmonary metastases...
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In a nutshell This study investigated the use of the chemotherapy regimen known as FOLFIRI with or without the addition of Aflibercept (Zaltrap) to treat metastatic colorectal cancer. Results showed that adding Aflibercept significantly increased the length of time patients survive and the length of time they survive without any disease...
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In a nutshell This review provided the long-term outcomes of the first human trial of the anti-PD-1 drug BMS-936558. It also evaluated whether restarting therapy for cancer recurrences can be effective. Results showed that anti-PD-1 drugs have clinical potential. Some background The PD-1 protein (or "programmed cell death-1" protein)...
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