In a nutshell The study evaluated the addition of pembrolizumab (Keytruda) to etoposide (Etopophos) and platinum chemotherapy drugs for patients with untreated extensive-stage (ES) small-cell lung cancer (SCLC). The study found that pembrolizumab improved progression-free survival (PFS; survival without cancer getting worse) when added to...
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In a nutshell This study examined the effectiveness and safety of adding durvalumab (Imfinzi) to platinum-etoposide to treat patients with small-cell lung carcinoma (SCLC). The authors found that durvalumab was well-tolerated and improved survival outcomes. Some background Small cell lung carcinoma (SCLC) is a type of lung cancer that...
Read MoreIn a nutshell This phase 2 trial will investigate the safety and effectiveness of different treatment combinations containing durvalumab (Imfinzi) in non-small cell lung cancer (NSCLC). The main outcome will be the objective response rate (ORR). The details Non-small cell lung cancer (NSCLC) is a common form of lung cancer. It is often diagnosed at...
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In a nutshell This study investigated the effectiveness of bevacizumab (Avastin) in combination with platinum-based chemotherapy in Hungarian patients with non-small-cell lung cancer (NSCLC). They found that this treatment combination was associated with improved patient survival. Some background The most common type of lung cancer is...
Read MoreIn a nutshell This trial aims to test the effectiveness of a new drug called RRx-001 in patients with small cell carcinoma. The main outcome measured will be how long the patients go without cancer growing or spreading (progression-free survival). The study is being conducted in the United States, Orange City, Florida. The details...
Read MoreIn a nutshell This study examined whether patients had a higher risk of thromboembolism depending on the chemotherapy drug they received. The study concluded that patients treated with carboplatin had no difference in the risk of thromboembolism compared to patients treating with cisplatin. Some background Chemotherapy is one of the most well-known...
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In a nutshell This study compared the safety and effectiveness of afatinib (Gilotrif) and erlotinib (Tarceva) as second-line treatments for advanced squamous cell carcinoma (SCC). Authors reported improved survival and disease progression with afatinib compared to erlotinib. Both treatments were associated with a good safety profile. Some background...
Read MoreIn a nutshell This trial investigated whether chemotherapy drugs belonging to the class of camptothecins (such as irinotecan or topotecan) used together with platinum analog chemotherapy (such as cisplatin or carboplatin) were better than the standard regimens in treating extensive disease small-cell lung cancer. Some background Standard treatment...
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