In a nutshell This study aimed to examine the risk of developing a secondary cancer after breast conserving therapy for early stage breast cancer patients. This study found that patients who have been treated for early stage breast cancer do not have a significantly higher risk of secondary cancers. Some background Women with early stage breast...
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In a nutshell This study aimed to examine breast conserving surgery (BCS) in combination with intra-operative radiotherapy (IORT) for patients who have previously had radiation treatment to the chest. This study found that BCS in combination with IORT provides good local control and overall survival in patients with previous chest...
Read MoreIn a nutshell This trial is examining the effectiveness of a probiotic (Primal Defense Ultra (R) Probiotic Formula) for the immune systems of patients with breast cancer. The main outcome to be measured is the number of cytotoxic T lymphocytes (CD8+), a type of white blood cell. This study is being conducted in the Mayo Clinic in...
Read MoreIn a nutshell This trial is examining the effectiveness of nivolumab (Opdivo) in combination with cabozantinib (Cometriq) for metastatic triple-negative breast cancer (cancer that is not dependent on hormones or HER2 for growth). The outcome to be measured will be the response rate of the cancer to this treatment. This study is...
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In a nutshell This study aimed to investigate the long-term effectiveness of oncoplastic surgery in treating breast cancer patients. This study concluded oncoplastic surgery was efficient and could be used instead of a mastectomy in treating breast cancer patients. Some background Breast conserving surgery (BCS) is used with radiotherapy...
Read MoreIn a nutshell This study investigated the complications that occur after intraoperative radiation therapy (IORT) treatment. The authors concluded that IORT is generally a safe treatment to use with BCS. Some background Breast-conserving surgery (BCS) treats breast cancer by removing just the tumor from the affected breast. IORT is sometimes...
Read MoreIn a nutshell This review outlined the recommended treatment options for invasive breast cancer. Some background Breast cancer is the most commonly diagnosed cancer in the world and it is the leading cause of cancer-related death in women. Breast cancer often begins in the milk ducts and lobules. In invasive breast cancer, the cancer moves...
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In a nutshell The authors aimed to assess and compare a number of surgical procedures used to treat and limit the risk of developing breast cancer. The study showed that there was no significant difference between contralateral prophylactic mastectomy (CPM) and breast-conserving treatment (BCT) on survival from breast cancer. Some background...
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In a nutshell The authors aimed to evaluate the effectiveness and safety of combining bevacizumab (Avastin) and chemotherapy prior to surgery in breast cancer. This study showed that adding bevacizumab to chemotherapy increased response rates among women with non-metastatic (has not spread) breast cancer. Some background...
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In a nutshell The authors aimed to determine whether or not there is a link between tumor budding, the environment of a tumor and prognosis (outlook) and survival from breast cancer. Some background Tumor budding refers to the 'clustering' of up to 5 cancer cells together to create a tumor 'bud'. Tumor budding is thought to be an...
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In a nutshell The authors aimed to determine the significance of cancer cells mutations (a permanent change in the genetic core of the cell) and their impact on a patient’s eligibility for certain therapy drugs. Some background Tumor suppressor genes (such as BRCA-1) protect cells from becoming cancerous through mechanisms that repair damage...
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In a nutshell The authors aimed to distinguish whether the characteristics of breast cancer could depend on the focality of the tumor. Some background Breast cancer can be characterized as 'unifocal', 'multifocal and 'multicentric'. This refers to the number of areas in which the cancer can be found (focality); unifocal...
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