In a nutshell The authors aimed to determine whether severe skin and nail infections observed in patients with breast cancer were due to a combination-chemotherapy treatment. Some background Trastuzumab (Herceptin) is a common drug used to treat patients with human epidermal growth factor 2 positive (HER2+) breast cancer. The HER2 protein can...
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In a nutshell The authors aimed to determine the risks of developing cardiac or heart problems while being treated with trastuzumab (Herceptin) for breast cancer. Some background Trastuzumab is a form of endocrine or hormone therapy used to treat patients with human epidermal growth factor 2 positive (HER2+) breast cancer. Since the approval of...
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In a nutshell This paper reviewed various strategies of preventing resistance to endocrine therapy. Some background Receptors are proteins found on cells that when activated can lead to cell growth and division. Estrogen receptors (protein found on cell) are one such example. Endocrine therapy is given to patients who have breast cancer with...
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In a nutshell This paper reviews the use of subcutaneous trastuzumab. Some background The human epidermal growth factor receptor 2 (HER2) is a protein involved in tumour cell growth and division. HER2 is associated with more aggressive disease and is a target for therapy. Trastuzumab (Herceptin) targets HER2 and is approved...
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In a nutshell This article evaluated the benefits of continuing trastuzumab treatment after disease progression in patients with HER2+ metastatic (spread to distant organs and tissues) breast cancer. Some background Breast cancer cells have on their surface some proteins called receptors. Hormones bind to these receptors causing changes in the...
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