In a nutshell This study evaluated the safety and effectiveness of first-line (primary treatment) BR (bendamustine, rituximab) in frail elderly patients with diffuse large B-cell lymphoma (DLBCL). This study concluded that the BR treatment showed promising effectiveness in these patients. Some background DLBCL is the most common type of...
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In a nutshell This study evaluated the significance of the albumin to globulin ratio in pretreated patients with diffuse large B-cell lymphoma. The study concluded that this ratio was useful for predicting treatment outcomes in these patients. Some background R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) is the most...
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In a nutshell This study compared the safety and effectiveness of two first-line chemotherapy regimens for diffuse large B-cell lymphoma. This study concluded that the R-THP-COP regimen was as effective as conventional R-CHOP for diffuse large B-cell lymphoma. Some background R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine,...
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In a nutshell This study investigated the safety and effectiveness of systemic chemotherapy after radiotherapy for early-stage follicular lymphoma. This study concluded that this combined treatment is more effective than radiotherapy alone for early-stage follicular lymphoma. Some background Radiotherapy can help control local disease in more than 90%...
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In a nutshell This study investigated the safety and effectiveness of ibrutinib (Imbruvica) plus venetoclax (Venclexta) for the treatment of mantle cell lymphoma. This study concluded that this regimen improved outcomes in patients with mantle cell lymphoma. Some background The standard treatment for mantle cell lymphoma (MCL)...
Read MoreIn a nutshell This study examined whether 6 or 8 cycles of R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy led to better survival outcomes in patients with newly diagnosed diffuse large B-cell lymphoma. This study concluded that outcomes following 6 or 8 cycles of R-CHOP-21 are similar for these patients. Some...
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In a nutshell This study investigated the safety and effectiveness of MOR208 in patients with relapsed or refractory (does not respond to treatment) non-Hodgkin’s lymphoma. This study concluded that MOR208 monotherapy was safe and showed promising results in these patients. Some background Chemoimmunotherapy is the current standard first-line...
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In a nutshell This study reviewed several studies involving patients with relapsed or refractory (does not respond to treatment) diffuse large B-cell lymphoma (DLBCL) who received radiation therapy (RT). The authors concluded that RT can improve outcomes and disease control for patients with localized disease. Some background Diffuse large B-cell...
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In a nutshell This study looked at the impact of rituximab treatment and gene mutations on the outcomes for elderly patients who did not respond to first line chemotherpy. The study concluded that patients who experienced treatment failure after first line rituximab and chemotherapy had poor outcomes, but rituximab improved patient outcomes when...
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In a nutshell This study looks at how often patients being treated for non-Hodgkin lymphoma develop pneumonitis, a swelling of the lungs. The study concluded that patients being treated with R-CDOP chemotherapy are at the highest risk of developing pneumonitis. Some background Pneumonitis is a dangerous and potentially deadly swelling of the...
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In a nutshell This study investigated whether interim FDG PET/CT scanning during chemotherapy helps predict risk for new DLBCL (diffuse large B-cell lymphoma) patients. This study concluded that this scanning improves the risk classifications used to predict outcomes for DLBCL patients. Some background Diffuse large B-cell lymphoma (DLBCL) is the most...
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In a nutshell This study looked at the effectiveness of chemotherapy followed by a single dose of radio-immunotherapy for treating patients with mantle cell lymphoma. The study concluded that radio-immunotherapy after standard chemotherapy is safe and effective to treat patients with mantle cell lymphoma. Some background Mantle cell lymphoma (MCL)...
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