In a nutshell This study evaluated the risk factors associated with delayed engraftment (DE) in patients who had stem cell transplantation (SCT). The authors found that patients receiving blood transfusions, those with low platelet levels, and those given low numbers of stem cells during SCT were more likely to experience DE. Some background...
Read MoreType of non Hodgkin’s lymphoma-Mantle cell lymphoma Posts on Medivizor
The effect of uric acid levels on the outcomes of patients having an allogeneic stem cell transplant
In a nutshell This study aimed to investigate the association of uric acid levels before a stem cell transplant and patient outcomes. This study concluded that high uric acid levels before the transplant led to an increased mortality. Some background Uric acid is a product of metabolic breakdown and is a normal component of urine. It can also be...
Read MoreHeart-related side effects associated with ibrutinib treatment
In a nutshell The study aimed to identify cardiovascular (heart and blood vessel) adverse drug reactions (CV-ADR) associated with ibrutinib treatment. This study concluded that severe and sometimes fatal cardiac events occur in patients exposed to ibrutinib. Some background Ibrutinib (Imbruvica) is a targeted therapy that can be used for...
Read MoreDoes stem cell transplantation affect the quality of life of older patients with NHL?
In a nutshell This study evaluated the quality of life reported by elderly patients with non-Hodgkin's lymphoma (NHL) after a stem cell transplant (SCT). The authors concluded that quality of life for these patients was very good following SCT. Some background Autologous SCT is the standard of care in first-line treatment for...
Read MoreSearching for patients with relapsed/unresponsive non-Hodgkin lymphoma to test an experimental antibody drug
In a nutshell This study is examining the effects of IGM-2323 for certain types of relapsed/unresponsive non-Hodgkin lymphoma. The main outcomes that will be measured are the side effects experienced by patients and the effectiveness of treatment. This trial is recruiting in the United States. The details Non-Hodgkin lymphoma (NHL) is a...
Read MoreEvaluating the TLI-ATG conditioning regimen before allogeneic stem cell transplantation in patients with lymphoma or leukemia
In a nutshell This study evaluated the safety and effectiveness of total lymphoid irradiation and anti-thymocyte globulin (TLI-ATG) conditioning before stem cell transplantation (SCT) in patients with lymphoma or leukemia. This study concluded that this regimen was well-tolerated and effective, especially for patients who had multiple lines of prior...
Read MoreWhich patients with mantle cell lymphoma may benefit from stem cell therapy?
In a nutshell This article reviewed which patients with mantle cell lymphoma benefitted most from a stem cell transplant. Some background Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin's lymphoma. It can be challenging to treat. There is no single standard treatment for patients with MCL. However, for young and fit patients, intensive...
Read MoreCan immune profiling help predict outcomes for patients with NHL after a stem cell transplant?
In a nutshell This study compared the outcomes of filgrastim (Neupogen) treatment with versus without plerixafor (Mozobil) in patients with B-cell non-Hodgkin's lymphoma (NHL) after a stem cell transplant. The authors concluded that certain immune cell biomarkers were associated with poorer long-term survival for these patients. Some...
Read MoreEvaluating the safety and effectiveness of the Shingrix vaccine for patients with lymphoma or leukemia
In a nutshell This study evaluated the safety and effectiveness of the herpes zoster vaccine (Shingrix) in patients with blood cancer who are receiving anti-cancer therapy. This study concluded that the Shingrix vaccine was effective in these patients, with manageable side effects. Some background Shingles is caused by a virus called herpes zoster....
Read MoreEvaluating SCR chemotherapy for patients with non-Hodgkin’s lymphoma
In a nutshell This study evaluated the effectiveness and safety of a new chemotherapy regimen for patients with non-Hodgkin’s lymphoma (NHL). This study concluded that this regimen was highly effective for these patients, but was associated with some side effects. Some background For patients with NHL, age is one determining factor for treatment...
Read MoreSearching for patients with relapsed or unresponsive non-Hodgkin lymphoma to try a new cell therapy
In a nutshell This Phase 2 study is evaluating the safety and effectiveness of a new T-cell therapy for B-cell non-Hodgkin’s lymphoma (NHL) that has come back or stopped responding to treatment. The main outcomes to be measured will be the number of patients who experience side effects and overall response after treatment. This trial is recruiting...
Read MoreManaging side effects of ibrutinib treatment
In a nutshell This study summarised the side effects of ibrutinib (Imbruvica) and how to manage them. Some background Ibrutinib is an FDA approved drug used to treat lymphoma and leukemia. It works on the immune cells in the body which may lead to many side effects. These include diarrhea, upper respiratory infections, bleeding, tiredness, and...
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