In a nutshell This study evaluated the outcomes of the R-BAC (rituximab, bendamustine, cytarabine) regimen for patients with relapsed or unresponsive mantle cell lymphoma (MCL). This study concluded that R-BAC was effective for these patients. Some background MCL is a rare but aggressive type of non-Hodgkin’s lymphoma (NHL). After initial...
Read MoreType of non Hodgkin’s lymphoma-Mantle cell lymphoma Posts on Medivizor
Evaluating Bendamustine-EAM conditioning chemotherapy for patients with mantle cell lymphoma
In a nutshell This study evaluated the safety and effectiveness of bendamustine-EAM (Be-EAM) chemotherapy for patients with mantle cell lymphoma (MCL) before a stem cell transplant. This study found that this regimen improved survival outcomes compared to standard regimens. Some background Stem cell transplants (SCT) remain the standard of care for...
Read MoreEvaluating long-term treatment with copanlisib for B-cell lymphoma
In a nutshell This looked at the safety and effectiveness of copanlisib (Aliqopa) for B-cell lymphoma that returned after previous treatment. This study found that long-term copanlisib treatment was safe and effective. Some background Indolent (painless) B-cell lymphoma is a slow-growing blood cancer. B-cell lymphoma that comes back or...
Read MoreEvaluating high-dose cyclophosphamide for patients with hard-to-treat B-cell non-Hodgkin’s lymphoma
In a nutshell This study evaluated the safety and effectiveness of high-dose cyclophosphamide (Cytoxan) for the treatment of relapsed or unresponsive non-Hodgkin’s lymphoma (NHL). This study concluded that high-dose cyclophosphamide was safe and effective for these patients. Some background Chemotherapy regimens remain a standard treatment...
Read MoreTrends in outcomes of allogeneic transplantation for elderly patients with non-Hodgkin lymphoma
In a nutshell This study evaluated the effectiveness of allogeneic stem cell transplants (allo-SCT) in elderly patients with non-Hodgkin’s lymphoma (NHL). This study found that allo-SCT has improved survival outcomes for these patients. Some background Allogeneic stem cell transplantation (allo-SCT) can be highly effective for patients with...
Read MoreHow effective and safe is acalabrutinib compared to other treatments for patients with mantle cell lymphoma?
In a nutshell This study compared the effectiveness and safety of acalabrutinib (Calquence) to other targeted therapies for patients with mantle cell lymphoma (MCL). The authors found that acalabrutinib was just as safe and more effective for these patients. Some background MCL is a type of non-Hodgkin's lymphoma treated in...
Read MoreWhat factors can predict the success of stem cell transplantation for patients with non-Hodgkin lymphoma?
In a nutshell This study evaluated the risk factors associated with delayed engraftment (DE) in patients who had stem cell transplantation (SCT). The authors found that patients receiving blood transfusions, those with low platelet levels, and those given low numbers of stem cells during SCT were more likely to experience DE. Some background...
Read MoreThe effect of uric acid levels on the outcomes of patients having an allogeneic stem cell transplant
In a nutshell This study aimed to investigate the association of uric acid levels before a stem cell transplant and patient outcomes. This study concluded that high uric acid levels before the transplant led to an increased mortality. Some background Uric acid is a product of metabolic breakdown and is a normal component of urine. It can also be...
Read MoreHeart-related side effects associated with ibrutinib treatment
In a nutshell The study aimed to identify cardiovascular (heart and blood vessel) adverse drug reactions (CV-ADR) associated with ibrutinib treatment. This study concluded that severe and sometimes fatal cardiac events occur in patients exposed to ibrutinib. Some background Ibrutinib (Imbruvica) is a targeted therapy that can be used for...
Read MoreDoes stem cell transplantation affect the quality of life of older patients with NHL?
In a nutshell This study evaluated the quality of life reported by elderly patients with non-Hodgkin's lymphoma (NHL) after a stem cell transplant (SCT). The authors concluded that quality of life for these patients was very good following SCT. Some background Autologous SCT is the standard of care in first-line treatment for...
Read MoreSearching for patients with relapsed/unresponsive non-Hodgkin lymphoma to test an experimental antibody drug
In a nutshell This study is examining the effects of IGM-2323 for certain types of relapsed/unresponsive non-Hodgkin lymphoma. The main outcomes that will be measured are the side effects experienced by patients and the effectiveness of treatment. This trial is recruiting in the United States. The details Non-Hodgkin lymphoma (NHL) is a...
Read MoreEvaluating the TLI-ATG conditioning regimen before allogeneic stem cell transplantation in patients with lymphoma or leukemia
In a nutshell This study evaluated the safety and effectiveness of total lymphoid irradiation and anti-thymocyte globulin (TLI-ATG) conditioning before stem cell transplantation (SCT) in patients with lymphoma or leukemia. This study concluded that this regimen was well-tolerated and effective, especially for patients who had multiple lines of prior...
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