In a nutshell This study aimed to compare outcomes of allogeneic hematopoietic stem cell transplant (alloHSCT) using cryopreserved (frozen) and fresh grafts in patients with blood cancers who received post-transplant cyclophosphamide (Cytoxan). This study concluded that cryopreservation (CP) does not affect the outcomes of HSCT in these patients....
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In a nutshell This study aimed to compare outcomes of allogeneic hematopoietic stem cell transplant (alloHSCT) using cryopreserved (frozen) and fresh grafts in patients with blood cancers who received post-transplant cyclophosphamide (Cytoxan). This study concluded that cryopreservation (CP) does...
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In a nutshell This study aimed to investigate fine motor (movement) impairments in children with acute lymphoblastic leukemia who are receiving maintenance treatment. This study concluded that a high percentage of these patients experienced fine motor difficulties. Some background Treatments for...
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In a nutshell The study evaluated occurrence, risk-factor, and exercise response of cardiac autonomic dysfunction (CAD) in adult survivors of childhood acute lymphoblastic leukemia (ALL). The authors found that over one-third of survivors developed CAD. It was related to lower exercise capacity. Some background Survivors of childhood ALL have reduced...
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In a nutshell The report recommends several treatment modifications for patients with leukemia during the high-risk period of the COVID-19 pandemic. The main recommendations are to reduce clinic visits, use less intensive chemotherapy, and care through telemedicine for effective treatment. Some background Managing patients with leukemia during...
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In a nutshell This study aimed to investigate the impact of maintenance treatment on cancer-related fatigue and sleep-wake rhythms in pediatric patients with acute lymphoblastic leukemia. This study concluded that sleep-wake rhythms are disturbed, physical activity levels lower and cancer-related fatigue levels higher...
Read MoreIn a nutshell The study evaluated treatment outcomes in patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) who continued blinatumomab (Blincyto; BL) after initial therapy. The authors found that long-term BL therapy can improve survival in these patients. Some background 45% of adults with ALL experience R/R...
Read MoreIn a nutshell This study examined the long-term survival of patients who received stem cell transplants (SCT) and compared them to the general population. The authors found that patients who received SCTs had almost the same chance of survival as the general population and identified factors that alter this chance. Some background Treatments such as...
Read MoreIn a nutshell This study aimed to investigate the activity of two types of asparaginase drugs in pediatric patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma. This study concluded that this type of treatment needs close monitoring for optimal effectiveness. Some background Asparaginase (ASNase) is a drug used in the treatment of...
Read MoreIn a nutshell This study evaluated if the intensified postinduction therapy is safe and effective to treat children with standard-risk (SR) B-cell acute lymphoblastic leukemia (B-ALL). The study concluded that the treatment excellently impacted survival among patients, but further intensifying the therapy might be unnecessary. Some background B-ALL is...
Read MoreIn a nutshell This study aimed to investigate if measurable residual disease (MRD) before transplant in patients with acute lymphoblastic leukemia (ALL) is associated with different outcomes in patients undergoing myeloablative total body irradiation (TBI)-based and chemotherapy (CT)-based conditioning. This study concluded that...
Read MoreIn a nutshell This study aimed to investigate the association of uric acid levels before a stem cell transplant and patient outcomes. This study concluded that high uric acid levels before the transplant led to increased mortality. Some background Uric acid is a product of metabolic breakdown and is a normal component of urine. It...
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