In a nutshell This study evaluated the safety and effectiveness of blinatumomab (Blincyto) for the treatment of children with relapsed or refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). The data showed that blinatumomab was safe and effective for these patients. Some background B-ALL is a type of cancer in which the body makes...
Read MoreType of ALL-B-lymphoblastic leukemia/lymphoma Posts on Medivizor
Evaluating therapies after CAR-T Cell treatment in patients with relapsed and refractory ALL
In a nutshell The study aimed to investigate if allogeneic hematopoietic stem cell transplant (alloHSCT) was a suitable treatment strategy for patients with relapsed/refractory (r/r) acute lymphoblastic leukemia (ALL) after chimeric antigen receptor (CAR) T-cell therapy. This study concluded that this was a suitable treatment...
Read MoreRestricting calories and nutrients to change chemotherapy effectiveness for acute lymphoblastic leukemia
In a nutshell This study aimed to investigate if restricting calories and nutrients from diet and exercise could change chemotherapy effectiveness in patients with B-cell acute lymphoblastic leukemia (ALL). This study concluded that restricting calories/nutrients via diet and exercise changed chemotherapy effectiveness and...
Read MoreCombination of CAR-T cell therapies for relapsed B cell acute lymphoblastic leukemia
In a nutshell This study aimed to investigate if combined CD19 and CD22 chimeric antigen receptor (CAR) T-cell therapies could be used to treat patients with relapsed acute lymphoblastic leukemia (ALL) after transplant. This study concluded that this combination improved long-term survival for these patients. Some...
Read MoreEvaluating the effectiveness and safety of inotuzumab ozogamicin for patients with relapsed/refractory acute lymphoblastic leukemia and non-Hodgkin lymphoma
In a nutshell This study investigated the effectiveness and safety of inotuzumab ozogamicin (Besponsa; INO) in patients with relapsed/refractory (r/r) acute lymphocytic leukemia (ALL) and non-Hodgkin lymphoma (NHL). The data showed that the treatment had good effectiveness and manageable side effects for these patients. Some background A high number...
Read MoreInotuzumab ozogamicin in patients with hard to treat, Philadelphia chromosome-positive acute lymphoblastic leukemia
In a nutshell This study aimed to investigate the effectiveness of inotuzumab ozogamicin (InO; Besponsa) in patients with Philadelphia chromosome-positive (Ph+) relapsed/refractory (r/r) acute lymphoblastic leukemia (ALL). This study concluded that this treatment is a good option for these patients. Some background Ph chromosome...
Read MoreBlinatumomab or inotuzumab ozogamicin as a bridge to stem cell transplant in relapsed/refractory B-cell acute lymphoblastic leukemia
In a nutshell This study aimed to evaluate the use of blinatumomab Blincyto; B) or inotuzumab ozogamicin (Besponsa; IO) as a bridge to stem cell transplant for patients with relapsed or refractory (unresponsive) B-cell acute lymphocytic leukemia (B-ALL). This study concluded that both treatments are safe and effective as a...
Read MoreEffects of stopping asparaginase therapy in children with acute lymphoblastic leukemia
In a nutshell The study evaluated outcomes after stopping PEG–asparaginase (PEG-ANAse; Oncaspar) and substituting with Erwinia ASNase (Elspar) in children with B-cell acute lymphoblastic leukemia (B-ALL). The main finding was that completely stopping ASNase was associated with poorer outcomes in such patients. Some background...
Read MoreThe effects of blinatumomab in patients with relapsed or unresponsive acute lymphoblastic leukemia in outside of clinical trials
In a nutshell The study evaluated the safety and effectiveness of blinatumomab (Blincyto) in patients with relapsed or unresponsive B-acute lymphoblastic leukemia (B-ALL) outside of clinical trials. The authors found that blinatumomab was safe and effective to treat such patients in real-world medical practice. Some background Relapsed...
Read MoreThe effects of blinatumomab therapy in patients with relapsed/refractory acute lymphoblastic leukemia before transplantation
In a nutshell The study investigated whether blinatumomab (Blincyto) can be used for salvage therapy before hematopoietic cell transplantation (HCT) in patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). The main finding was that blinatumomab can be safely and effectively used in patients with r/r B-ALL before HCT. Some...
Read MoreMinimal residual disease response leading to better outcomes for patients with relapsed/refractory acute lymphoblastic leukemia after treatment with blinatumomab
In a nutshell This study aimed to evaluate the relationship between minimal residual disease response and outcomes in patients with relapsed/unresponsive B-cell precursor acute lymphoblastic leukemia who were treated with blinatumomab. This study concluded that achieving minimal residual disease response leads to better outcomes for...
Read MoreStem cell transplant after blinatumomab in patients with relapsed or unresponsive acute lymphoblastic leukemia
In a nutshell This study aimed to investigate the outcomes for patients who underwent allogeneic hematopoietic stem cell transplant after treatment with blinatumomab. This study concluded that survival was driven by the response to study treatment and by salvage status regardless of transplant status. Some...
Read More