In a nutshell This trial is aiming to investigate the effectiveness of stereotactic body radiotherapy (SBRT) boost for the treatment in patients with high-risk prostate cancer (PCa). The main outcome that will be measured will be the quality of life (QoL) of patients. This study is being carried out in Ontario, Canada. The details PCa is the...
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In a nutshell The authors determined the long-term outcomes of active surveillance (watchful waiting) in patients with low risk of prostate cancer. Some background Active surveillance is an option, often used in patients with favorable-risk prostate cancer (Stage I/II, confined to prostate with low risk of spread or...
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In a nutshell The authors determined the risk factors that led to disease reclassification (change in grade/status of the disease) in prostate cancer patients under active surveillance. Some background Active surveillance is common in early-stage prostate cancer management. It involves active monitoring of patients for any changes in symptoms or...
Read MoreIn a nutshell The authors aimed to determine long-term outcomes in prostate cancer patients following treatment with watchful waiting or prostate surgery. Some background In early prostate cancer, watchful waiting is a form of treatment that involves closely monitoring a patient to determine any signs of cancer progression, but does not involve...
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In a nutshell The authors aimed to evaluate the use of Gleason scores in predicting the outlook of metastatic prostate cancer. Some background The Gleason grading system is from 2-10. It describes how different the cancer cells look from normal cells and predicts the likelihood of the tumor spreading. The lower the score, the less likely it...
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In a nutshell This paper presents results from phase I and II clinical trials evaluating the safety and efficacy of two targeted therapies – dabrafenib and trametinib – given in combination for metastatic melanoma patients with BRAF mutations. Some background BRAF is a protein that plays a role in cell division and growth. About 50% of...
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In a nutshell This study investigated the use of the chemotherapy regimen known as FOLFIRI with or without the addition of Aflibercept (Zaltrap) to treat metastatic colorectal cancer. Results showed that adding Aflibercept significantly increased the length of time patients survive and the length of time they survive without any disease...
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In a nutshell The present study evaluated the risk of developing colorectal cancer (CRC) in Lynch syndrome carriers who were followed by colonoscopies at 1 to 2-year intervals. Some background Lynch syndrome is an inherited condition that predisposes patients to cancer of the large intestine (CRC). Lynch syndrome can also cause cancers of the...
Read MoreIn a nutshell This study aimed to determine the rate of cancer cases in patients with polyps that were removed surgically. Factors that predict the presence of cancer in these polyps were also investigated. The results confirm the fact that the best therapeutic option for polyps that cannot be removed endoscopically is radical surgery. Some background...
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In a nutshell The aim of this study was to establish the criteria for selecting the best candidates to receive a second breast–conserving surgery (BCS) after ipsilateral breast tumor recurrence (IBTR- reappearance of a breast tumor on the same side). Some background Some patients with primary breast cancer who receive BCS and...
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In a nutshell This study evaluated the efficacy of home-based lifestyle counseling and coaching program in achieving adequate lifestyle changes in older sedentary breast cancer survivors. Some background Older breast cancer survivors are at risk of developing secondary cancers, heart diseases and declining self-care capacity. Previous...
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In a nutshell This study evaluated the efficacy of home-based lifestyle counseling and coaching program in achieving adequate lifestyle changes in older sedentary colorectal cancer (CRC) survivors. Some background Older CRC survivors are at risk of developing secondary cancers, heart diseases and declining self-care capacity. Previous...
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