In a nutshell This study looked at a combination of irinotecan (Camptosar) and platinum-based drugs, for treating patients with extensive-stage small cell lung cancer. The authors concluded that this combination has the potential to improve the outcomes for these patients. Some background Extensive stage small-cell lung cancer (ES-SCLC) is...
Read MoreTreatment(s) now being considered-Chemotherapy Posts on Medivizor
Which chemotherapy drugs are better after surgery for patients with NSCLC?
In a nutshell This study evaluated the effectiveness of fluorouracil (Adrucil) chemotherapy after surgery in patients with non-small-cell lung cancer (NSCLC). The authors concluded that treatment with fluorouracil resulted in prolonged recurrence-free survival compared to standard chemotherapy regimens. Some background Adjuvant therapy is given in...
Read MoreChemoradiation and hypothyroidism in patients with Hodgkin Lymphoma.
In a nutshell This study investigated the development of hypothyroidism in patients with Hodgkin lymphoma after chemoradiation therapy. Patients were more likely to develop hypothyroidism after intensity modulated radiation therapy than after 3-dimensional conformal radiation therapy. Some background Patients with Hodgkin lymphoma (HL) are commonly...
Read MoreLooking for patients with triple negative inoperable breast cancer to test a new treatment option atezolizumab
In a nutshell This trial is examining the effectiveness of atezolizumab (Tecentriq) when used with chemotherapy in patients with inoperable, recurrent triple-negative breast cancer. The main outcome to be measured will be the overall survival (time from treatment until death from any cause) of participants. The...
Read MoreLooking for patients with triple negative breast cancer to test atezolizumab
In a nutshell This trial is examining the effectiveness of chemotherapy and atezolizumab (Tecentriq), given before surgery, for triple negative breast cancer. The main outcomes to be measured will be response in the breast tissue and lymph nodes and survival. The details Triple negative breast cancer is not dependent on the HER2 receptors or...
Read MoreShould men with castration-resistant metastatic prostate cancer receive further hormone therapy?
In a nutshell This study aimed to discover the optimal timing of hormone therapies in combination with androgen-deprivation therapy (ADT) for patients with metastatic hormone-sensitive prostate cancer. This study found that treatment with a second hormone therapy after prostate cancer becomes immune to hormone treatment is associated...
Read MorePost-surgery chemotherapy in early rectal cancer is associated with improved outcomes
In a nutshell This study investigated the safety of localized surgery followed by chemotherapy compared with total mesorectal excision (TME; bowel and lymph nodes around the tumor are removed) in early stages (T0 to T1) of rectal cancer. Researchers suggested that local surgery followed by chemotherapy improves long term outcomes in early stages of...
Read MoreUmbilical cord blood transplantation for Hodgkin’s lymphoma
In a nutshell This study investigated the outcomes of umbilical cord blood transplantation in pretreated patients with Hodgkin’s lymphoma. The authors concluded that this procedure is a feasible treatment option for these patients. Some background Patients with relapsed or refractory (does not respond to treatment) Hodgkin’s lymphoma have...
Read MoreIs pirarubicin safer and more effective than doxorubicin in R-CHOP for diffuse large B-cell lymphoma?
In a nutshell This study compared the safety and effectiveness of two first-line chemotherapy regimens for diffuse large B-cell lymphoma. This study concluded that the R-THP-COP regimen was as effective as conventional R-CHOP for diffuse large B-cell lymphoma. Some background R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine,...
Read MoreOxaliplatin based treatments as adjuvant chemotherapy treatment in colon cancer patients
In a nutshell This study investigated the effectiveness of a 3-month oxaliplatin-based chemotherapy treatment after surgery in patients with stage 3 colon cancer. Researchers suggested 6-months of treatment is associated with better outcomes. Some background The current standard treatment for stage 3 colon cancer patients is surgery followed by...
Read MoreGenetics used to guide breast cancer chemotherapy treatment
In a nutshell This study examined if the presence of certain genes had an effect on endocrine (hormone) treatment alone compared to chemoendocrine (chemotherapy and hormone) treatment for breast cancer. The study concluded that endocrine and chemoendocrine had the same effectiveness in women with certain genetic factors. Some background Breast cancer...
Read MoreAlopecia after breast cancer treatment
In a nutshell This study aimed to find out how common persistent hair loss (alopecia) is after breast cancer chemotherapy, and how to prevent it. The authors found that persistent alopecia was present in all forms of chemotherapy but was worse with docetaxel (Taxotere) and could be prevented by using a scalp cooling technique. Some background...
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