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Treatment(s) now being considered-Bone marrow transplant Posts on Medivizor

The effects of brentuximab vedotin in patients with unresponsive Hodgkin Lymphoma

Posted by on Sep 18, 2018 in Hodgkin's lymphoma | 0 comments

In a nutshell This study investigated the effects of brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma after stem cell transplant. Brentuximab vedotin appeared to be effective and safe for these patients. Some background Many patients with Hodgkin lymphoma (HL) are cured by standard therapies. However, some patients lose...

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Is tandem stem cell transplantation effective in high risk relapsed/refractory Hodgkin lymphoma

Posted by on May 26, 2018 in Hodgkin's lymphoma | 0 comments

In a nutshell This study investigated the effect of tandem stem cell transplantation (SCT) in patients with high-risk relapsed/refractory Hodgkin Lymphoma (HL). The main finding was that patients treated with tandem SCT had greater progression-free survival than those without. Some background A SCT involves the transfer of stem cells into the patient to...

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What are the long-term outcomes for HL patients receiving plerixafor before a stem cell transplant?

Posted by on May 7, 2018 in Hodgkin's lymphoma | 0 comments

In a nutshell This study compared the long-term outcomes of Hodgkin’s lymphoma (HL) patients who received plerixafor (Mozobil) to those who did not prior to autologous stem cell transplantation (autoSCT). This study concluded that plerixafor-treated patients had similar outcomes as patients who received conventional regimens. Some background...

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Does high-dose GBM chemotherapy lead to better post-stem cell transplant outcomes compared to BEAM in refractory or relapsed Hodgkin’s lymphoma patients?

Posted by on May 3, 2018 in Hodgkin's lymphoma | 0 comments

In a nutshell This study investigated the outcomes of primary refractory or relapsed Hodgkin’s lymphoma (HL) patients who received GBM (gemcitabine, busulfan, melphalan) or BEAM (carmustine, etoposide, cytarabine, melphalan) chemotherapy before autoSCT (autologous stem cell transplantation). This study concluded that GBM improved patient outcomes...

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What are the long-term outcomes after plerixafor and G-CSF before stem cell transplantation?

Posted by on Mar 8, 2018 in Non-Hodgkin lymphoma | 0 comments

In a nutshell This study investigated the long-term outcomes of patients with non-Hodgkin’s lymphoma (NHL) or multiple myeloma (MM) who received plerixafor (Mozobil) or placebo combined with G-CSF (granulocyte colony stimulating factor) before a stem cell transplant (SCT). This study concluded that adding plerixafor to G-CSF did not negatively...

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Do two cycles of stem cell therapy lead to longer progression free survival in relapsed or refractory HL patients?

Posted by on Feb 27, 2018 in Hodgkin's lymphoma | 0 comments

In a nutshell This study determined if progression-free survival (time from treatment before disease progression) could be improved in patients with relapsed or refractory Hodgkin’s lymphoma (HL) who received two cycles (tandem) of autologous hematopoietic stem cell transplantation (AHSCT). This study concluded that tandem AHSCT appears effective...

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Haploidentical stem cell transplant after failed autologous stem cell transplant: Lower risk of disease progression compared to identical-matched donors

Posted by on Dec 20, 2017 in Hodgkin's lymphoma | 0 comments

In a nutshell This study examined the effect of donor type on allogeneic stem cell transplant outcomes in patients with relapsed Hodgkin lymphoma. This study reported reduced disease progression in patients with partially matched donors compared to identical matches.  Some background While Hodgkin lymphoma is a curable disease, some patients...

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Use of brentuximab vedotin, nivolumab, and pembrolizumab for treating patients with relapsed or refractory Hodgkin lymphoma

Posted by on Sep 4, 2017 in Hodgkin's lymphoma | 0 comments

In a nutshell This study looked at the use of brentuximab vedotin (Adcetris), nivolumab (Opdivo), and pembrolizumab (Keytruda) in treating patients with relapsed or refractory Hodgkin lymphoma. The study concluded that all three medications are very effective at treating patients with relapsed or refractory Hodgkin lymphoma.  Some...

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The use of donor stem cell transplantation in patients with relapsed Hodgkin lymphoma

Posted by on Apr 14, 2017 in Hodgkin's lymphoma | 0 comments

In a nutshell The authors examined haploidentical (matched donor) stem cell transplantation (haplo-SCT) as a treatment for patients who relapsed after autologous stem cell transplantation. The study concluded that haplo-SCT is a valid treatment for patients with relapsed Hodgkin lymphoma. Some background Most cases of Hodgkin lymphoma (HL) can be...

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Use of brentuximab vedotin in Hodgin lymphoma patients before allogenic stem cell transplantation

Posted by on Apr 14, 2017 in Hodgkin's lymphoma | 0 comments

In a nutshell This study examined the outcomes for patients who received brentuximab vedotin before allogenic stem cell transplantation. The authors concluded that patients treated with brentuximab vedotin had generally good outcomes. Some background Hodgkin lymphoma (HL) is generally considered a curable disease. However, some patients will not...

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