In a nutshell This study presents updated longer-term data on recurrence-free survival (RFS) for pembrolizumab (Keytruda) after surgery for stage 3 melanoma. The study showed that pembrolizumab has a lasting and improving effect on RFS as a treatment after surgery. Some background For patients with stage 3 melanoma,...
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In a nutshell The authors aimed to determine whether dacarbazine was better as a single or combination therapy when treating malignant melanoma. Some background Dacarbazine (DTIC) has been the most used and effective treatment option in malignant melanoma, however it has a low response rate (reduction in the signs or symptoms of cancer) of...
Read MoreIn a nutshell This article evaluated lymph node ratio (LNR) as a prognostic factor for stage III melanoma patients. Some background Melanoma often spreads beyond the original tumor site. Once cancer cells spread to nearby lymph nodes (these are referred to as cancer-positive lymph nodes) the disease is categorized as stage III melanoma, which...
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In a nutshell The aim of this analysis was to determine the prognostic factors that can lead to the best results of Interferon treatment (as IFN or PEG-IFN) on patients with high-risk melanoma. The results indicate that tumor stage and ulceration were predictive factors for the efficacy of IFN/PEG-IFN therapy. Some background Malignant melanoma is...
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In a nutshell The present article evaluated the time interval and site of relapse (return of the cancer) as well as survival rates in stage III melanoma patients who were considered cured after treatment. Some background Stage III melanoma is skin cancer that has spread to the nearby lymph nodes. Further classification (III A, III B and III...
Read MoreIn a nutshell The present article evaluated the benefits of adjuvant radiotherapy (RT) compared to observation alone after therapeutic lymphadenectomy (TL) for melanoma patients with a high risk of lymph node relapse (return of cancer to the lymph nodes). Some background Patients with a history of melanoma are at increased risk of developing...
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