In a nutshell This study investigated the benefits of repeated cytoreductive surgery (CRS) and hyperthermic peritoneal chemotherapy (HIPEC) in patients with advanced colorectal cancer. Researchers suggested that repeated treatment improves the survival of patients with advanced colorectal cancer, without an increase in side effects. Some background...
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In a nutshell This study compared the effectiveness of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) with other treatment options in patients with colorectal cancer (CRC) and peritoneal metastasis (PM; when cancer spreads to the abdominal lining). Researchers suggested that CRS + HIPEC brings the greatest...
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In a nutshell This review analyzed the effectiveness of combined surgery and chemotherapy for colorectal cancer which has spread to the wall of the abdomen. Some background Many colorectal cancer patients are diagnosed after the cancer has already spread. Cancer that has spread to the peritoneum (the abdominal wall) is termed “colorectal...
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In a nutshell This study compared two treatments for peritoneal metastasis in colorectal cancer (cancer that has spread to the lining of the abdomen). Some background Peritoneal metastasis is a serious complication of colorectal cancer. It is not usually treatable with standard chemotherapy, which is injected into veins or given by...
Read MoreIn a nutshell This study compared the outcome of patients with colorectal or appendix cancer that had spread to the peritoneum (the lining of the abdominal cavity). Some background Peritoneal metastasis indicates that the initial cancer has spread to the peritoneum. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS/HIPEC) is...
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In a nutshell This study investigated two treatment options for patients with cancer that has spread to the peritoneum (the lining of the abdominal cavity). Some background A common location for colorectal cancer to spread is the peritoneum. The best way to treat patients with peritoneal invasion is with cytoreductive surgery plus intraperitoneal...
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In a nutshell This study investigated whether cancer that has spread to the peritoneal surface (the lining of the abdominal cavity) can be treated as effectively as cancer that has spread to the liver in colorectal cancer patients. Some background The liver is the most common metastatic site (site for the cancer to...
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In a nutshell This study evaluated whether patients with colorectal cancer and peritoneal carcinomatosis (cancer spread to the abdominal cavity) can be cured of their cancer using cytoreductive surgery and intraperitoneal chemotherapy. Some background Colorectal cancer or CRC (cancer of the large intestine) often spreads to the peritoneum (a...
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In a nutshell This article evaluated whether the use of a minimally invasive diagnostic technique called laparoscopy before surgery to treat peritoneal carcinomatosis improves the selection of patients who can benefit the most from treatment. The authors of the study found that laparoscopy can be used to select patients for whom surgery may be a...
Read MoreIn a nutshell This study will compare two procedures to deliver chemotherapy into the abdominal cavity following surgery to remove colorectal cancer spread to the peritoneum (the lining of the abdominal cavity). The primary outcome of the study is disease-free survival, or the length of time without any evidence of cancer. The details...
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In a nutshell The present study evaluated the long-term quality of life (QOL) for patients with peritoneal carcinomatosis (PC) who had cytoreductive surgery (CRS) and HIPEC (hyperthermic perioperative chemotherapy). Main findings: patients who survived the procedure regained their baseline (pre-operative) QOL within 6-12 months after...
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Colorectal cancer (CRC) often presents with peritoneal metastases, which have a poor outcome. This means that cancer cells have spread from the colon, appendix, or rectum to the peritoneum (a sheath that covers the abdominal organs). This article argues the pros and cons of a combined treatment for patients with peritoneal metastases from CRC. This...
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