In a nutshell This study looked at the use of surgery for spread disease (metastases) in patients with advanced melanoma when other whole-body treatments had failed. It found that surgical removal of metastases improved the outcomes of these patients. Some background Advanced melanoma can spread to many places in the body. It is usually...
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In a nutshell This study examined the impact of the pattern of metastatic spread on the effectiveness of enzalutamide in combination with androgen deprivation therapy (ADT) for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). The data showed that the combination has good outcomes in men with bone and/or lymph node...
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In a nutshell This study looked at the safety and effectiveness of isolated limb infusion in elderly patients with melanoma of the skin on a limb (arm/leg) that could not be surgically removed. The study found isolated limb infusion to be safe and effective in elderly patients. Some background lsolated limb perfusion (ILP) is a method of...
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In a nutshell The authors aimed to determine whether dacarbazine was better as a single or combination therapy when treating malignant melanoma. Some background Dacarbazine (DTIC) has been the most used and effective treatment option in malignant melanoma, however it has a low response rate (reduction in the signs or symptoms of cancer) of...
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In a nutshell The authors aimed to determine whether diphencyprone could be used as a topical treatment in cutaneously metastatic melanoma. Some background Metastatic (spread of the cancer) melanoma is typically treated with topical and intralesional immunotherapies (restore or enhance the immune systems ability to fight). Topical therapy is...
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In a nutshell In this phase 3 clinical trial, researchers compared the safety and efficacy of vemurafenib to the standard chemotherapy drug for melanoma, dacarbazine. Some background A genetic defect (mutation) in protein called BRAF is present in approximately 50% of melanomas. BRAF helps cells grow and multiply, so BRAF mutations are responsible...
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In a nutshell This phase 3 clinical trial compared the safety and efficacy of dabrafenib to a standard treatment for melanoma, dacarbazine in patients with metastatic melanoma. Some background BRAF is a protein that helps cells grow and multiply. A genetic defect can cause the BRAF protein to malfunction (BRAF mutation). A BRAF mutation is...
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