In a nutshell The study investigated whether a pediatric (designed for children) therapy for acute lymphoblastic leukemia (ALL) can treat adolescents and young adults (AYA) with standard-risk (SR) ALL. The main finding was that a full pediatric therapy could effectively treat such patients. Some background There are major differences between therapies...
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In a nutshell This study examined the long-term effectiveness of different treatment strategies for acute lymphoblastic leukemia (ALL) in young people. This study concluded that augmented treatment for rapid early responders was most beneficial, with improved survival at 10 years. Some background ALL is a cancer of the bone marrow. It leads to...
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In a nutshell This study looked at the effect of using busulfan to delete blood cancer cells from the system before replacing them with normal cells in the treatment of leukaemia. The study found that busulfan therapy was effective in removing blood cancer cells before replacement, in the treatment of high-risk acute leukaemia. Some background Acute...
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In a nutshell This study reviewed CAR-T cell therapy, a new type of immunotherapy, for chronic lymphocytic leukemia (CLL). Some background Chimeric antigen receptor (CAR) T-cell therapy helps the immune system to fight cancer cells. In this treatment, immune cells (the T-cells) are removed from the blood. The T-cells are then genetically modified...
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In a nutshell This study analyzed the results of 37 studies comparing myeloablative therapy and reduced intensity conditioning (RIC) before stem cell transplantation in patients with chronic lymphocytic leukemia (CLL). This study concluded that RIC was associated with lower mortality and better survival compared to myeloablative therapy. Some...
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