In a nutshell This study analyzed the use of allogeneic hematopoietic stem cell transplantation (alloHSCT) therapy following first remission in children with newly diagnosed, high-risk acute myeloid leukemia (AML) compared to chemotherapy. This study supports the use of alloHSCT for children with AML that are at greater. Some background Childhood AML...
Read More
In a nutshell This study evaluated the effectiveness of CPX-351 (Vyxeos; daunorubicin, cytarabine) versus standard chemotherapy for older patients with high-risk acute myeloid leukemia (AML). This study found that CPX-351 improved long-term outcomes for these patients. Some background AML is a cancer of the blood and bone marrow. AML can also...
Read More
In a nutshell This study aimed to investigate if postinduction central nervous system (CNS; brain and spine) protection with intrathecal (injection into the spine) triple therapy (ITT) would improve the outcomes for pediatric patients with acute lymphoblastic leukemia (ALL) when compared to intrathecal methotrexate (MTX; Otrexup)...
Read More
In a nutshell This study aimed to investigate the safety and effectiveness of alisertib combined with induction chemotherapy in patients with high-risk acute myeloid leukemia. This study concluded that this combination was safe and effective in these patients. Some background Alisertib is a type of targeted...
Read MoreIn a nutshell This study will investigate the effects of high-pressure oxygen on the transplant of umbilical cord blood stem cells in patients with blood cancers. The main outcome that will be measured is the time it takes for white blood cells to recover after treatment. This trial is recruiting in New York, US. The details Stem cell transplant (SCT)...
Read More
In a nutshell This study examined the long-term effectiveness of different treatment strategies for acute lymphoblastic leukemia (ALL) in young people. This study concluded that augmented treatment for rapid early responders was most beneficial, with improved survival at 10 years. Some background ALL is a cancer of the bone marrow. It leads to...
Read More
In a nutshell This study reviewed the evidence for stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL). Researchers found that SCT is an effective treatment option in patients with high risk of ALL coming back. Matched donors or siblings are the preferred stem cell donors. Some background ALL is a cancer of the bone...
Read More
In a nutshell This study observed the safety and effectiveness of the drug Gemtuzumab Ozagamicin (Mylotarg) when given to children with acute myeloid leukemia unresponsive to treatment. The authors found the treatment to be effective in children who became unresponsive to bone marrow transplant therapy. Some background Acute Myeloid...
Read More
In a nutshell This study observed the effects of a protein treatment called interferon-alpha in patients with acute leukemia unresponsive to transplant therapy. The authors found that this treatment was effective in improving treatment response and survival in these patients. Some background Interferon-alpha (IFN-a) is a type of...
Read More
In a nutshell This study looked at the effect of using busulfan to delete blood cancer cells from the system before replacing them with normal cells in the treatment of leukaemia. The study found that busulfan therapy was effective in removing blood cancer cells before replacement, in the treatment of high-risk acute leukaemia. Some background Acute...
Read More
In a nutshell This study reviewed CAR-T cell therapy, a new type of immunotherapy, for chronic lymphocytic leukemia (CLL). Some background Chimeric antigen receptor (CAR) T-cell therapy helps the immune system to fight cancer cells. In this treatment, immune cells (the T-cells) are removed from the blood. The T-cells are then genetically modified...
Read More
In a nutshell This study examined stem cell transplant outcomes across acute myeloid leukemia (AML) patients with different disease status. Researchers reported superior survival after a stem cell transplant among patients in second complete remission. Some background Stem cell transplantation is considered the most effective therapy for...
Read More
