In a nutshell This study evaluated the effectiveness and safety of aprocitentan (ACT-132577) for lowering blood pressure (BP) in patients with resistant or uncontrolled hypertension (high BP). The data showed that aprocitentan was effective in lowering the BP after 4 weeks with a sustained effect after 40 weeks compared to a placebo with...
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In a nutshell This trial will evaluate the effectiveness and safety of a device to manage hypertension. The main outcomes will be the rate of adverse events (AEs) and blood pressure (BP) changes. This trial is taking place in the United States. The details Hypertension or high blood pressure (BP) is a common and serious condition. Patients with...
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In a nutshell This phase 3 trial will investigate the effects of aprocitentan for the treatment of resistant (difficult to control hypertension. The main outcome to be measured will be change in systolic blood pressure (SBP; the first number in the reading). The details Hypertension or high blood pressure is a common condition. To reduce BP,...
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In a nutshell This study reviewed the diagnosis and treatment of resistant hypertension. Some background Hypertension or high blood pressure (BP) is a common condition. Patients with hypertension have a higher risk of cardiovascular (heart and circulatory system) disease. There is also an increased risk of stroke, disability and death. Hypertension...
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In a nutshell The aim of this trial is to investigate if modifications to exercise and diet have any effect on neurocognitive functions (functions controlled by the brain). The main outcomes to be investigated are changes in executive function (behavioral control and decision making), processing speed (the ability to process information) and...
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In a nutshell This study examined the effect of renal denervation on blood pressure in patients with moderate resistant hypertension. The authors concluded that renal denervation can significantly reduce blood pressure in patients with moderate resistant hypertension. Some background Patients with hypertension have a higher resting blood pressure...
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In a nutshell This review examined evidence on the effectiveness of aldosterone antagonists in patients with resistant hypertension (RH). The authors concluded that aldosterone antagonists are effective in reducing blood pressure in patients with RH. Some background Patients with resistant hypertension (RH) have blood pressure levels...
Read MoreIn a nutshell This study examined the effect of continuous positive airway pressure (CPAP) treatment on blood pressure in patients with obstructive sleep apnea (OSA). The authors concluded that CPAP treatment resulted in reduced blood pressure in patients with resistant hypertension and OSA. Some background Obstructive sleep apnea (OSA) is when...
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In a nutshell This study examined the safety and effectiveness of renal denervation compared to intense drug treatment for resistant hypertension. The authors concluded that renal denervation achieved a decrease in blood pressure similar to that seen with intense drug treatment. Some background Patients with hypertension have a higher resting...
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In a nutshell This study evaluated the safety and efficacy of a procedure called renal artery sympathetic denervation (RASD) for patients with high blood pressure or hypertension (HTN) resistant to maximal treatment. Some background HTN is the leading treatable cardiovascular risk factor worldwide. More than 50% of the patients do not achieve the...
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In a nutshell This study evaluated a new therapy called catheter-based renal sympathetic denervation (RSD) for patients with resistant high blood pressure. Some background Hypertension is a condition in which blood pressure (BP) exceeds 140/90 mmHg at rest. Systolic blood pressure (SBP) is the higher value (measured while the...
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