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How effective is umbralisib as treatment for patients with relapsed or refractory low-grade lymphoma?

How effective is umbralisib as treatment for patients with relapsed or refractory low-grade lymphoma?

Posted by on Apr 11, 2021 in Non-Hodgkin lymphoma | 0 comments

In a nutshell The authors assessed the safety and effectiveness of umbralisib (Ukoniq) in patients with relapsed or refractory (r/r) indolent (low-grade) non-Hodgkin lymphoma (iNHL).   The study concluded that umbralisib was well tolerated and effective for patients with r/r iNHL. Some background iNHL is a slow-growing cancer of...

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Can PDE5 inhibitors improve male fertility?

Can PDE5 inhibitors improve male fertility?

Posted by on Apr 11, 2021 in Infertility | 0 comments

In a nutshell This review looked at whether phosphodiesterase 5 (PDE5) inhibitors such as sildenafil (Viagra) can improve male fertility. It found that these medications improve sperm concentration, shape, and movement. Some background PDE5 inhibitors are the most common treatment for erectile dysfunction (ED). These medications increase the...

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How does endometriosis surgery affect IVF outcomes?

How does endometriosis surgery affect IVF outcomes?

Posted by on Apr 11, 2021 in Infertility | 0 comments

In a nutshell This review looked at the effect of endometriosis surgery before in vitro fertilization (IVF). It found that surgery led to better pregnancy outcomes for patients with severe endometriosis. Some background Endometriosis is a condition in which cells from the lining of the uterus grow on the ovaries, Fallopian tubes, or other places...

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Does adding chemotherapy to cytoreductive surgery improve the outcome of patients with peritoneal metastases from colorectal cancer?

Does adding chemotherapy to cytoreductive surgery improve the outcome of patients with peritoneal metastases from colorectal cancer?

Posted by on Apr 11, 2021 in Colorectal cancer | 0 comments

In a nutshell This study evaluated the benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery (CS) for the treatment of colorectal cancer (CRC) that has spread to the peritoneum (the lining of the abdomen that covers all abdominal organs). The study found that HIPEC added to CS did not improve the outcomes of...

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Comparing ublituximab plus ibrutinib versus ibrutinib alone for patients with relapsed or refractory high-risk chronic lymphocytic leukemia

Comparing ublituximab plus ibrutinib versus ibrutinib alone for patients with relapsed or refractory high-risk chronic lymphocytic leukemia

Posted by on Apr 11, 2021 in Leukemia | 0 comments

In a nutshell This study investigated the safety and effectiveness of adding ublituximab (TG-1101) to ibrutinib (Imbruvica) treatment for patients with relapsed or refractory (r/r) chronic lymphocytic leukemia (CLL). The data showed that adding ublituximab to ibrutinib significantly improved the overall response rate compared to ibrutinib alone...

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Can low disease activity be achieved with a modern treatment approach in pregnant women with rheumatoid arthritis?

Can low disease activity be achieved with a modern treatment approach in pregnant women with rheumatoid arthritis?

Posted by on Apr 10, 2021 in Rheumatoid Arthritis | 0 comments

In a nutshell This study evaluated whether a modern treatment approach is suitable in patients with rheumatoid arthritis (RA) that were pregnant or intended to become pregnant. The authors concluded that low disease activity (LDA) and remission are possible with a modern approach in these women. Some background RA is an inflammatory disease....

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Which statin is best for preventing strokes?

Which statin is best for preventing strokes?

Posted by on Apr 10, 2021 in Stroke | 0 comments

In a nutshell This study compared several statin medications for the prevention of cardio-cerebrovascular (CCV) events such as strokes, heart attacks of death. It found that atorvastatin (Lipitor), pitavastatin (Livalo), rosuvastatin (Crestor), and simvastatin (Zocor) were all equally effective at preventing CCV events. Some background The most common...

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Does surgery with animal grafts improves the outcomes of men with Peyronie’s disease?

Does surgery with animal grafts improves the outcomes of men with Peyronie’s disease?

Posted by on Apr 10, 2021 in Erectile dysfunction | 0 comments

In a nutshell This study compared the effectiveness of two different types of xenografts (transplant of a tissue or organ derived from an animal) in the treatment of Peyronie’s disease (PD). Researchers suggested that xenografts might be a good and safe treatment option for these patients. Some background PD is a disorder in which scar...

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Comparing the activity and safety of [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer

Comparing the activity and safety of [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer

Posted by on Apr 10, 2021 in Prostate cancer | 0 comments

In a nutshell This study compared the effectiveness and safety of lutetium-177 [177Lu]-PSMA-617 (177LuPSMA) versus cabazitaxel (Jevtana) for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC). The data showed that 177LuPSMA treatment showed a higher response with fewer side effects in these patients. Some...

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Real-world outcomes of fulvestrant as first-line treatment of postmenopausal women with advanced breast cancer.

Real-world outcomes of fulvestrant as first-line treatment of postmenopausal women with advanced breast cancer.

Posted by on Apr 10, 2021 in Breast cancer | 0 comments

In a nutshell This study investigated the effectiveness of fulvestrant (Faslodex) as a first-line treatment for postmenopausal women with estrogen receptor-positive (ER+) metastatic breast cancer (BC) in a real-world setting. The data showed that the outcomes of these patients in the real-world setting were similar to clinical trials...

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