In a nutshell This study reviewed the current management for overactive bladder in a real-world setting. The authors concluded that behavioral therapy and antimuscarinic drugs were the preferred therapies, corresponding to guideline recommendations. Some background Overactive bladder (OAB) occurs when the bladder muscle is too active....
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Evaluating the AdVance XP male sling for male stress urinary incontinence
In a nutshell This study aimed to investigate the use of the AdVance XP male sling for urinary incontinence and in men after prostate cancer treatment. This study found that this procedure is promising for these patients. Some background Sling surgery is the most common surgery to treat stress urinary incontinence (SUI). SUI means...
Read MoreTumor budding as a prognostic factor for treatment outcomes in patients with stage 2 colon cancer
In a nutshell This study investigated the role of tumor budding (TB) in predicting the best treatment for stage 2 colon cancer. Researchers suggested that TB could improve the effect of chemotherapy after surgery in these patients. Some background Stage 2 colorectal cancer accounts for one-third of patients who undergo curative surgery. Prognostic...
Read MoreIs levodopa-carbidopa intestinal gel an effective treatment for patients with Parkinson’s disease?
In a nutshell This study investigated the effectiveness and safety of levodopa-carbidopa intestinal gel (LCIG; Duodopa) in the treatment of patients with Parkinson's disease. Researchers suggested that LCIG alone is a safe and effective option as a treatment for these patients. Some background Parkinson disease affects brain cells. These cells...
Read MoreLeflunomide – a review of its use in the treatment of juvenile idiopathic arthritis
In a nutshell This study investigated the use of leflunomide (Arava) in juvenile idiopathic arthritis (JIA). They found that this medication may be useful in managing JIA in patients resistant or intolerant to methotrexate. Some background Juvenile idiopathic arthritis (JIA) is caused by inflammation in the joints. JIA is...
Read MoreDoes thalidomide improve outcomes for elderly patients with multiple myeloma?
In a nutshell This study evaluated CyBorD (cyclophosphamide, bortezomib, dexamethasone) with or without a switch to another regimen mid-treatment for elderly patients with multiple myeloma (MM). The authors concluded that CyBorD was promising for these patients and that switching to VTD chemotherapy during treatment provided better...
Read MoreEvaluating different doxorubicin doses for patients with diffuse large B-cell lymphoma
In a nutshell This study evaluated three different chemotherapy regimens with varying doses of doxorubicin (Adriamycin) for patients with diffuse large B-cell lymphoma (DLBCL). This study concluded that R-CEOP70 could be safely used instead of R-CHOP50, while R-CEOP90 may be recommended for younger patients. Some background DLBCL is one of the most...
Read MoreBexagliflozin for patients with type 2 diabetes
In a nutshell This study wanted to evaluate the safety and effectiveness of bexagliflozin in patients with type 2 diabetes (T2D). The study found that this treatment was safe and significantly improved the outcomes of these patients. Some background Bexagliflozin is a new medication for treating T2D. It is part of a larger class of...
Read MoreAn update of sorafenib as a maintenance agent after stem cell transplant for acute myeloid leukemia
In a nutshell This study aimed to investigate if sorafenib (Nexavar) would be a suitable maintenance agent for patients with acute myeloid leukemia who received a stem cell transplant. This study concluded that sorafenib is a safe and effective maintenance agent in these patients. Some...
Read MoreLong-term risk of infections after treatment of childhood leukemia
In a nutshell This study aimed to compare the risk of infections after treatment completion for pediatric leukemia survivors and the general population. This study concluded that there was a significant association between history of leukemia therapy and increased risk of infections. Some background Infections are a common...
Read MoreNilotinib for patients with chronic phase chronic myeloid leukemia
In a nutshell This study aimed to investigate outcomes for patients with chronic-phase chronic myeloid leukemia who received nilotinib as a first-line treatment. This study concluded that nilotinib is a valuable treatment option for these patients. Some background Nilotinib (Tasigna) is a targeted therapy...
Read MoreCan metformin help reduce the risk of developing neurodegenerative disease in elderly patients with T2D?
In a nutshell This study examined if metformin (Glucophage) helped reduce the risk of neurodegenerative disease in elderly patients with Type 2 diabetes (T2D). The authors found that patients taking metformin for more than two years had a lower risk of brain degeneration diseases compared to patients not taking metformin. Some...
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