In a nutshell This study compared treatments for fatty liver disease in patients with type 2 diabetes (T2D). They found that liraglutide (Victoza) reduced liver fat significantly, improved liver function, and led to weight loss and better blood sugar control. Some background Half of the patients with T2D can have liver disease...
Read MoreIn a nutshell This trial is testing the effectiveness of once-daily vs thrice-daily oral insulin in patients with type 1 diabetes (T1D). The main outcome is the amount of injected insulin used, and the second outcome is the amount of time blood glucose levels are within specific ranges. This study is being conducted in Orange County, California,...
Read MoreIn a nutshell This study is examining the safety and effectiveness of a new insulin plan for people with type 2 diabetes (T2D) that are already being treated with basal insulin. The new insulin being evaluated is a once-a-week administration of insulin instead of daily injections of basal insulin, which should be substantially more convenient for...
Read MoreIn a nutshell This phase 3 clinical trial is investigating the safety and effectiveness of dapagliflozin (Forxiga) and saxagliptin (Onglyza) in young people with type 2 diabetes (T2D). The main outcome to be measured will be change in HbA1c (measures average blood glucose over the last 3 months) after 6 months of treatment. The details Dapagliflozin...
Read MoreIn a nutshell This study investigated the outcomes of a very low-carbohydrate (ketogenic) diet versus a moderate-carbohydrate diet in adults with prediabetes or Type 2 diabetes. This study concluded that the adults on the low-carbohydrate diet had greater reductions in HbA1c levels (average blood glucose over 3 months), body weight, and medication usage...
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In a nutshell This phase 3 trial aims to evaluate the safety and effectiveness of alogliptin (Nesina) in pediatric patients with type 2 diabetes. The main outcome to be investigated is the effect on blood glucose control after 26 weeks of treatment. The details Managing blood glucose levels is key in the treatment of type 2 diabetes....
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In a nutshell This study investigated whether early control of blood sugar levels reduced the risk of developing heart disease. The authors concluded that those who managed to control their blood-sugar early were less likely to develop heart disease. Some background Patients with type 2 diabetes are advised to control blood sugar levels as...
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In a nutshell This study investigated if insulin degludec was as effective as insulin glargine U100 in reducing rates of hypoglycemia (low blood sugar) in patients with type 1 diabetes. They found that patients receiving insulin degludec had a reduced risk of hypoglycemia compared to those receiving insulin glargine U100. Some background...
Read MoreIn a nutshell The main objective of this trial is to determine whether islet cell transplantation (ICT) using anti-thymocyte globulin (ATG) is a safe and effective treatment for type I diabetes. The main outcome to be measured is number of patients who no longer need insulin therapy following transplantation. This trial is being held in Duarte,...
Read MoreIn a nutshell The main objective of this trial is to determine the safety and efficacy of dapagliflozin (Farxiga) in type 2 diabetes patients aged 10-24 years. The main outcome to be measured is the change in average blood glucose (sugar) levels. The details Dapagliflozin is a type 2 diabetes treatment that removes glucose from the blood and...
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In a nutshell This study investigated whether adding dapagliflozin (Farxiga/Forxiga) to liraglutide (Victoza) and insulin therapy would improve blood glucose control and promote weight loss in patients with type 1 diabetes (T1D). Improved blood glucose control and weight loss was recorded, however increased ketosis (raised ketone acids in the blood)...
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In a nutshell This study compared the outcomes of bariatric surgery between patients with early onset (before age 40) and late onset (after age 40) type 2 diabetes. They found that bariatric surgery had more successful outcomes in those with early onset type 2 diabetes. Some background As the number of patients with type 2 diabetes (T2D) continues...
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