In a nutshell This study evaluated the effectiveness of insulin glargine 100U/ml (iGlar; Lantus) and lixisenatide (Lixi; Lyxumia) combined (iGlarLixi; Soliqua) compared with each of the two drugs alone in patients with type 2 diabetes (T2D) that was uncontrolled with 2 anti-diabetic oral drugs. The data showed that iGlarLixi...
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In a nutshell This study explored the effects of different second-line therapies combined with metformin (Glucophage) in patients with type 2 diabetes (T2D). The data showed that metformin combinations with a sulfonylurea (SU) had the lowest weight loss, the smallest effect of lowering blood glucose, and an overall, reduced health...
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In a nutshell This study evaluated the outcomes of cotadutide (MEDI0382) treatment in patients with type 2 diabetes (T2D) and obesity. This study concluded that cotadutide treatment improved glycemic (blood sugar) control and weight loss in these patients. Some background T2D is commonly associated with obesity. About 70% of patients with T2D...
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In a nutshell In this study, the authors evaluated the effectiveness of adding dapagliflozin (Farxiga) to insulin therapy in patients with uncontrolled type 2 diabetes (T2D). The study showed that compared to increasing insulin doses, dapagliflozin improved glucose control while reducing weight and hypoglycemia (dangerously low blood...
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In a nutshell This study looked at how weekly semaglutide (Ozempic) affected patients with type 2 diabetes (T2D) in a real-world setting. It found that semaglutide improved blood sugar control compared to the treatments patients were already taking. Some background For patients with T2D, the body does not respond well to the hormone insulin, which...
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In a nutshell This study compared the effectiveness and safety of biphasic insulin aspart 30 (BIAsp 30; NovoMix 30) alone or with metformin (Glucophage), in patients with inadequately controlled type 2 diabetes (T2D). The authors concluded that combined therapy may be preferred in patients with high cardiovascular risk and/or a body...
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In a nutshell This study examined the effectiveness of adding henagliflozin (SHR3824) to metformin (Glucophage) in patients with uncontrolled type 2 diabetes (T2D). The authors concluded that the addition of 5 mg or 10 mg of henagliflozin to metformin was well-tolerated and effective in these patients. Some background...
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In a nutshell This study looked at the ertugliflozin (Steglatro) for patients with type 2 diabetes (T2D) and heart disease. It found that ertugliflozin improved both blood glucose control, body weight, and blood pressure. Some background T2D is a condition in which the levels of glucose (sugar) in the blood are too high. T2D is related to...
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In a nutshell This study compared the safety and effectiveness of liraglutide (Victoza) to insulin glargine (Lantus) on glycemic (blood glucose) control in patients with type 2 diabetes (T2D) after hospital discharge. The authors concluded that liraglutide treatment led to improved glycemic control and greater weight loss compared to...
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In a nutshell This study looked at the effect of bariatric surgery (BS; weight loss surgery) on complications of type 2 diabetes (T2D). It found that patients who had BS had fewer vision, foot, and kidney complications. Some background Diabetes is a long-lasting health condition that involves high levels of sugar in the blood. Over time, high blood...
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In a nutshell This study tested the ability of henagliflozin (SHR3824) in controlling blood glucose levels in patients with type 2 diabetes (T2D). The authors found that henagliflozin alone was able to control glucose levels, reduce body weight and blood pressure in these patients. Some background Insulin is a hormone produced by the...
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In a nutshell This review compared the effects of two types of bariatric surgery (weight loss surgery) on type 2 diabetes (T2D) remission over five years. It found that Roux-en-Y gastric bypass (RYGB) led to better diabetes outcomes than sleeve gastrectomy (SG). It also found that both types of surgery led to improvements in T2D. Some background T2D...
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