In a nutshell This study aimed to investigate using rituximab (Rituxan) and high-dose methylprednisolone (HDMP; Medrol) as a treatment for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). This study concluded that this treatment is a good option for elderly and frail patients and can work as a bridge to...
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In a nutshell This study examined whether it is safe to switch from intravenous to subcutaneous rituximab (Rituxan) during first-line treatment of non-Hodgkin's lymphoma (NHL). The authors concluded that subcutaneous rituximab was safe and effective, and improved quality of life for patients. Some background Rituximab is a standard...
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In a nutshell This trial will compare the effectiveness of two maintenance therapies in patients with multiple myeloma (MM) after a stem cell transplant (SCT). The main outcome to be measured will be the average time from treatment until death due to any cause. The details Maintenance therapy is commonly given after SCT to help delay...
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In a nutshell This trial is examining the effectiveness of crenolanib after salvage chemotherapy for relapsed or unresponsive acute myeloid leukemia (AML) with FLT3 activating mutations. The main outcome would be survival without complications from leukemia 3 years after the treatment has finished. The details AML is a type of blood...
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In a nutshell This study investigated the safety and effectiveness of a new chimeric antigen receptor (CAR) T cell therapy for relapsed or refractory (does not respond to treatment) multiple myeloma (MM). This study found that this cell therapy was effective, but it had significant side effects. Some background MM is a type of cancer of the...
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In a nutshell This trial examined whether aggressive radiation would cause severe side effects in patients over 80 years old with early stage non-small-cell lung cancer (NSCLC). The authors concluded that SBRT is safe and tolerable for older patients. Some background Stereotactic body radiation therapy (SBRT) is a type of radiation that delivers...
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In a nutshell This study compared weak opioids and low-dose morphine in providing pain relief for moderate cancer pain. Researchers concluded that low-dose morphine is more suitable as pain management for moderate cancer pain than weaker pain relievers. Some background The guidelines for cancer pain relief developed by the World Health...
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The article reviews drugs that were approved by the US Food and Drug Administration (FDA) for the treatment of Metastatic Breast Cancer (MBC) in the last 20 years. The authors summarize the clinical studies which lead to FDA approval. ‘First-line therapy’ is the initial treatment used to reduce cancer burden. It is usually the standard...
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In a nutshell This study investigated the benefits of chemotherapy to treat inoperable (that cannot be removed through surgery) metastases from colorectal cancer (CRC). Some background When CRC is discovered early, the preferred method of treatment is surgery to remove the cancer along with some surrounding healthy tissue. Chemotherapy is often...
Read MoreIn a nutshell In this study, researchers examined how adjuvant chemotherapy benefits colon cancer patients over the age of 75. Some background Adjuvant chemotherapy (the addition of chemotherapy to another treatment, such as surgery) has been shown to benefit survival in multiple trials and is considered common practice for patients with advanced...
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In a nutshell This trial compared the survival of lung cancer patients, between patients receiving standard radiation therapy and those receiving radiation therapy given on alternative schedules (hyperfractionated or accelerated). Some background This research was prompted by recent findings that suggest a benefit with hyperfractionated or...
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In a nutshell This article evaluated the effects of chemotherapy after the surgical removal of liver and lung metastases on survival in patients with colorectal cancer (CRC). Some background Metastatic CRC is cancer that has spread from the large intestine to distant organs or tissues in the body. The parts of the body mainly affected by...
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