In a nutshell This phase 2 trial is evaluating how well CD8+ memory T-cell therapy works in patients with leukemia or lymphoma after a stem cell transplant (SCT). The main outcome to be measured will be the number of patients who have full chimerism (donor cells work completely and only donor cells can be identified after transplant) after therapy. This...
Read MorePerformance status -1 – Slightly symptomatic Posts on Medivizor
Searching for patients with relapsed or unresponsive follicular lymphoma to trial a new drug
In a nutshell This trial will evaluate the effects of a new treatment parsaclisib (INCB050465) in relapsed or unresponsive follicular lymphoma (FL). Response rate, survival, and side effects will be the main outcomes measured. The details Many patients are cured with treatments for follicular lymphoma (FL). Some, however, lose response to therapy...
Read MoreSearching for patients to try a new combination of treatments for relapsed or unresponsive Hodgkin lymphoma.
In a nutshell This study will investigate the effects of pembrolizumab (Keytruda) and targeted radiation therapy for relapsed or unresponsive Hodgkin lymphoma (HL). This study will measure the rate of complete response (disappearance of all cancer). The details Many patients are cured with treatments for HL. Some patients lose response to...
Read MoreSearching for patients to try a new therapy for non-responsive leukemia/lymphoma after stem-cell transplant.
In a nutshell This study will investigate the effects of ibrutinib (Imbruvica) in patients with non-responsive leukemia/lymphoma after a stem-cell transplant. The main outcome that will be measured is the time after treatment before patients experience cancer worsening. This trial is recruiting in the United States. The details Some patients with...
Read MoreSearching for patients to try a new therapy for non-responsive lymphoma after stem-cell transplant.
In a nutshell This study will investigate the effects of ibrutinib (Imbruvica) in patients with non-responsive lymphoma after a stem-cell transplant. The main outcome that will be measured is the time after treatment before patients experience cancer worsening. This trial is recruiting in the United States. The details Some patients with lymphoma lose...
Read MoreSearching for patients to try a new therapy for non-responsive lymphoma after stem-cell transplant.
In a nutshell This study will investigate the effects of ibrutinib (Imbruvica) in patients with non-responsive lymphoma after a stem-cell transplant. The main outcome that will be measured is the time after treatment before patients experience cancer worsening. This trial is recruiting in the United States. The details Some patients with lymphoma...
Read MoreSearching for patients with previously untreated DLBCL to try this new treatment combination
In a nutshell This study is comparing the effectiveness of R-CHOP chemotherapy with or without enzastaurin (Kinenza) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL). The main outcome to be measured will be overall survival at the end of the study. The details The current standard first-line treatment for DLBCL is R-CHOP...
Read MoreSearching for patients with relapsed or unresponsive classical HL to try this new treatment option
In a nutshell This Phase 3 trial is evaluating the effectiveness of brentuximab vedotin (Adcetris) with or without nivolumab (Opdivo) for patients with relapsed or unresponsive classical Hodgkin’s lymphoma (cHL). The main outcome to be measured will be survival outcomes at 4 years after treatment. The details Treatment remains...
Read MoreSearching for patients with lymphoma to try a new combination treatment
In a nutshell This study will investigate the effects of a new combination of pembrolizumab (Keytruda) and MK-4280 for the treatment of non-Hodgkin lymphoma (NHL). Side effects and response to treatment will be the main effects measured. The details Pembrolizumab and MK-4280 are both targeted therapies for blood cancers. This means that they...
Read MoreSearching for patients with chronic lymphocytic leukemia to test zanubrutinib compared to ibrutinib
In a nutshell This trial is looking at the effectiveness of zanubrutinib compared to ibrutinib in the treatment of patients with unresponsive or relapsed chronic lymphocytic leukemia (CLL). The main outcome to be measured will be overall response rate. The study will be carried out in the United States. The details Chronic...
Read MoreSearching for patients with blood cancer to test new stem cell transplant option
In a nutshell This phase 3 trial is comparing the safety and effectiveness of NiCord stem cell treatment with stem cells taken from the umbilical cord. The main outcome to be measured is the time to neutrophil engraftment (white blood cells accepted by the body that start to grow and make new cells) following transplantation. The details...
Read MoreSearching for patients with early stage Hodgkin lymphoma to try brentuximab vedotin and nivolumab
In a nutshell This study is investigating the effectiveness of brentuximab vedotin (Adcetris) and nivolumab (Opdivo) in early-stage Hodgkin lymphoma (HL). The main outcome that will be measured will be survival without cancer worsening after 18 months. The details There are many different treatments for HL. Each treatment or combination of...
Read More
