In a nutshell This review examined the safety and effectiveness of once weekly GLP-1 receptor agonists for the treatment of type 2 diabetes. The authors concluded that once weekly GLP-1 RA drugs are convenient, safe and effective for the treatment of type 2 diabetes. Some background Patients with type 2 diabetes (T2D) initially produce...
Read MoreIn a nutshell This study compared the effectiveness and safety of treatment with IDegLira, to treatment with either insulin degludec or liraglutide in type 2 diabetes. Some background Metformin (Glucophage) is typically the first treatment for type 2 diabetes. Commonly, additional drugs are eventually...
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In a nutshell This study investigated the effectiveness of two drug combinations in type 2 diabetes and compared the associated cardiovascular and overall risk. Some background Diabetes is associated with increased cardiovascular risk (including heart attack or stroke). Metformin (Glucophage) is recommended...
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In a nutshell This study investigated the effect of 3 different therapy combinations on the occurrence of cardiovascular disease in type 2 diabetes. Some background There are a number of types of drugs that can be used to treat diabetes. Metformin (Glucophage) decreases glucose production, and is often the first choice of treatment...
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In a nutshell This study examined whether sitagliptin delays the need for insulin therapy in type 2 diabetics in comparison to a sulfonylurea. Some background Patients with type 2 diabetes (T2D) initially produce insulin (hormone which lowers blood sugar levels) but it fails to work in the body. Drugs such as metformin (Glucophage) aim to help...
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In a nutshell This study evaluated the long-term safety and effectiveness of dulaglutide (Trulicity) compared to sitagliptin (Januvia) in the treatment of type 2 diabetes. Some background Type 2 diabetes is a progressive disease. While it initially can be treated through diet and lifestyle changes, patients will...
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In a nutshell This study compared the safety and efficacy of saxagliptin (Onglyza) plus metformin (Glucophage) to that of glimepiride (Amaryl) plus metformin in elderly type 2 diabetes patients. Some background Elderly type 2 diabetes patients have a higher risk of hypoglycemia (dangerously low blood...
Read MoreIn a nutshell This study explored the effectiveness and safety of adding two glucose-lowering drugs, saxagliptin (Onglyza) and dapagliflozin (Farxiga), to patients with type 2 diabetes uncontrolled by metformin (Glucophage) alone. Some background Type 2 diabetes is a progressive disease. While some patients may initially be able to control their...
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In a nutshell This study compared the effects of adding either basal insulin or a glucagon-like peptide-1 (GLP-1) receptor agonist to the treatment regimens of patients with uncontrolled type 2 diabetes. Some background Type 2 diabetes is a progressive disease. While patients may be able to control their disease with diet and lifestyle changes at...
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In a nutshell This study evaluated the effectiveness and safety of adding vildagliptin (Galvus, Zomelis, Jalra) to a metformin (Glucophage) and sulfonylurea (Amaryl, DiaBeta) combination in patients with type 2 diabetes. Some background Type 2 diabetes is a chronic progressive disease that occurs due to resistance to insulin. There are several...
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In a nutshell This study evaluated the safety and effectiveness of once-daily insulin detemir and insulin glargine when added to metformin therapy in type 2 diabetes patients. Some background Initiating insulin therapy with a once-daily basal insulin therapy (long-acting insulins used to provide stable blood insulin levels throughout the day) in...
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In a nutshell The authors evaluated the effectiveness and safety of canagliflozin for type 2 diabetes that could not be controlled with metformin therapy. Some background Metformin (Glucophage) is a recommended first-line drug therapy for type 2 diabetes that decreases glucose production in the liver, increases insulin sensitivity and enhances...
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