Non-insulin oral drug(s)-Glucophage (Metformin) - Page 3 of 3 Posts on Medivizor
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Non-insulin oral drug(s)-Glucophage (Metformin) Posts on Medivizor

Take two or take three? Adding saxagliptin and dapagliflozin to metformin

Posted by on Mar 30, 2015 in Diabetes mellitus | 0 comments

In a nutshell This study explored the effectiveness and safety of adding two glucose-lowering drugs, saxagliptin (Onglyza) and dapagliflozin (Farxiga), to patients with type 2 diabetes uncontrolled by metformin (Glucophage) alone. Some background Type 2 diabetes is a progressive disease. While some patients may initially be able to control their...

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Metformin didn’t work – what’s next? Adding a second treatment in uncontrolled type 2 diabetes

Posted by on Feb 2, 2015 in Diabetes mellitus | 0 comments

In a nutshell This study compared the effects of adding either basal insulin or a glucagon-like peptide-1 (GLP-1) receptor agonist to the treatment regimens of patients with uncontrolled type 2 diabetes. Some background Type 2 diabetes is a progressive disease. While patients may be able to control their disease with diet and lifestyle changes at...

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Uncontrolled diabetes? Another drug might help!

Posted by on Sep 29, 2014 in Diabetes mellitus | 0 comments

In a nutshell This study evaluated the effectiveness and safety of adding vildagliptin (Galvus, Zomelis, Jalra) to a metformin (Glucophage) and sulfonylurea (Amaryl, DiaBeta) combination in patients with type 2 diabetes. Some background Type 2 diabetes is a chronic progressive disease that occurs due to resistance to insulin. There are several...

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Is insulin detemir or insulin glargine more effective in type 2 diabetes?

Posted by on Jul 14, 2014 in Diabetes mellitus | 0 comments

In a nutshell This study evaluated the safety and effectiveness of once-daily insulin detemir and insulin glargine when added to metformin therapy in type 2 diabetes patients. Some background Initiating insulin therapy with a once-daily basal insulin therapy (long-acting insulins used to provide stable blood insulin levels throughout the day) in...

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Can canagliflozin help when metformin therapy can’t control diabetes?

Posted by on Jul 4, 2014 in Diabetes mellitus | 0 comments

In a nutshell The authors evaluated the effectiveness and safety of canagliflozin for type 2 diabetes that could not be controlled with metformin therapy. Some background Metformin (Glucophage) is a recommended first-line drug therapy for type 2 diabetes that decreases glucose production in the liver, increases insulin sensitivity and enhances...

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Addition of insulin glargine to combination therapy with oral anti-diabetic drugs: a promising therapeutic option for type 2 diabetes

Posted by on May 6, 2014 in Diabetes mellitus | 0 comments

In a nutshell This study compared the effects of adding insulin glargine treatment  to metformin (Glucophage), glimepiride (Amaryl) or their combination in patients with uncontrolled type 2 diabetes mellitus. Some background Hyperglycemia (high blood glucose) in type 2 diabetes mellitus arises from a combination...

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Is dapagliflozin add-on therapy beneficial?

Posted by on Nov 5, 2013 in Diabetes mellitus | 0 comments

In a nutshell This trial evaluated the efficacy of dapagliflozin (Forxiga) in patients with type 2 diabetes mellitus (T2DM) uncontrolled with sitagliptin (Januvia), with or without metformin (Glucophage).  Some background T2DM is a condition in which the cells of the body are failing to use insulin properly (insulin resistance), resulting in...

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Evaluating safety and efficacy of a new drug for patients with type 2 diabetes mellitus

Posted by on Aug 15, 2013 in Diabetes mellitus | 0 comments

In a nutshell This study assessed the efficacy and safety of adding gemigliptin versus sitagliptin to metformin treatment in patients with type 2 diabetes mellitus (T2DM). Some background T2DM is a condition in which patients have high blood glucose levels (hyperglycemia) when cells fail to respond to the normal actions of the hormone insulin or...

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AZD1656 reduces blood sugar levels in type 2 diabetes, but loses efficacy over time

Posted by on Aug 15, 2013 in Diabetes mellitus | 0 comments

In a nutshell In this study researchers examined the effect of a new drug, AZD1656, and its ability to control blood sugar levels in type 2 diabetic (T2D) patients. Some background Many different drugs, such as metformin (glucophage), are used to control blood sugar levels in T2D patients. However, not all patients manage to properly control their...

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Comparing the effects of exenatide versus glimepiride in achieving glycaemic control in patients with type 2 diabetes mellitus poorly controlled with metformin

Posted by on Jun 2, 2013 in Diabetes mellitus | 0 comments

In a nutshell This study compared the efficacy and safety of exenatide versus glimepiride in achieving glycaemic (blood sugar) control in patients with type 2 diabetes mellitus (T2DM) uncontrolled by metformin.  Some background T2DM is a condition in which patients have high blood sugar levels (hyperglycemia). Metformin (Glucophage) is the...

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