In a nutshell This trial is examining the effectiveness of tirzepatide compared to insulin glargine in patients with type 2 diabetes who are also at high risk for heart disease. The main outcome to be measured will be a change in HbA1c (a blood test that measures average blood sugar levels in the past 3 months) over 52 weeks. The details In type 2...
Read MoreNon-insulin oral drug(s)-Glucophage (Metformin) Posts on Medivizor
Searching for patients with type 2 diabetes to test the effectiveness of the drug semaglutide compared to other standard treatments
In a nutshell The aim of this study is to test the effectiveness of semaglutide (Ozempic) in the treatment of type 2 diabetes compared to other currently used treatments. The main outcome to be measured is the change in HbA1c (blood test measuring blood sugar control over 3 months). This study is being conducted in the United States. The details...
Read MoreLooking for young people with type 2 diabetes to try dapagliflozin and saxagliptin
In a nutshell This phase 3 clinical trial is investigating the safety and effectiveness of dapagliflozin (Forxiga) and saxagliptin (Onglyza) in young people with type 2 diabetes (T2D). The main outcome to be measured will be change in HbA1c (measures average blood glucose over the last 3 months) after 6 months of treatment. The details Dapagliflozin...
Read MoreInvestigating a combination of ertugliflozin and sitagliptin in people with type 2 diabetes
In a nutshell This study investigated the effectiveness and safety of ertugliflozin (Steglatro) plus sitagliptin (Januvia), compared to either drug used alone, in people with type 2 diabetes (T2D). It was determined that the combination was better at controlling blood glucose levels, without increasing the risk of side effects. Some background...
Read MoreCould ertugliflozin be a useful third-line therapy for type 2 diabetes?
In a nutshell This study assessed whether patients with uncontrolled diabetes would benefit from adding ertugliflozin to their treatment regime. The authors concluded that ertugliflozin improved blood sugar control among those unable to do so with the combination of metformin (Glucophage) and sitagliptin (Januvia) alone. Some...
Read MoreLiraglutide versus sitagliptin in people with type 2 diabetes
In a nutshell This study compared the effectiveness and safety of liraglutide (Victoza) and sitagliptin (Januvia) in people with type 2 diabetes (T2D) who were being treated with metformin (Glucophage). It was determined that liraglutide controls blood glucose levels better, and results in more weight loss than sitagliptin. However, liraglutide...
Read MoreCan early control of blood sugar levels reduce the risk of heart disease?
In a nutshell This study investigated whether early control of blood sugar levels reduced the risk of developing heart disease. The authors concluded that those who managed to control their blood-sugar early were less likely to develop heart disease. Some background Patients with type 2 diabetes are advised to control blood sugar levels as...
Read MoreDoes autoinjected exenatide suspension improve blood glucose control in patients with type 2 diabetes on metformin therapy?
In a nutshell This study assessed the safety and effectiveness of a new formulation of exenatide compared to sitaglipitin in patients with sub-optimal blood sugar control taking metformin. This study concluded that exenatide reduced blood sugar levels over 3 months more effectively than sitaglipitin. Some background There are many blood...
Read MoreDoes post-meal exercise reduce blood sugar levels in type 2 diabetes?
In a nutshell The authors aimed to determine whether prescribed walking taken after meals was more effective in patients with type 2 diabetes compared to walking on a single occasion at any time of the day. The authors concluded that physical activity programs should be specifically designed for post-meal activity, particularly when meals are...
Read MoreCan a multivitamin prevent vitamin B-12 deficiency caused by metformin?
In a nutshell This study aimed to determine the relationship between metformin (Glucophage) use in older adults with diabetes and vitamin B-12 concentrations, and assess whether B-12 supplementation can alter this. Metformin use was shown to be linked to lower B-12 levels, and multivitamin use may be protective against this. Some background...
Read MoreNew: Effectiveness of lixisenatide does not depend on beta-cell function in type 2 diabetes
In a nutshell This study examined whether lixisenatide (Adlyxin) was effective in patients with differing levels of beta cell function (the cells that produce insulin). The authors found that lixisenatide decreased blood glucose (blood sugar) levels regardless of beta cell function. Some background Type 2 diabetes (T2D) is a progressive disease....
Read MoreWhat are the cardiovascular effects of liraglutide?
In a nutshell This study looked at the cardiovascular effects of liraglutide (Victoza) in patients with type 2 diabetes who were at high cardiovascular risk. It found that patients taking liraglutide were less likely to experience death by cardiovascular causes, a nonfatal heart attack or nonfatal stroke over the course of the...
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