In a nutshell This study aimed to investigate the safety and risk of disease recurrence in breast cancer survivors who were treated with systemic (whole-body) hormone replacement therapy (HRT). This study concluded that use of HRT increased the risk of disease recurrence in these patients. Some background Some breast...
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In a nutshell This study evaluated the long-term effectiveness of adding ribociclib (Kisqali) to endocrine (hormone) therapy in pre-/perimenopausal patients with hormone receptor-positive (HR+)/HER2-negative (HER2-) advanced breast cancer (BC). The data showed that adding ribociclib to hormone therapy significantly improved survival outcomes than hormone...
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In a nutshell This study evaluated the effects and outcomes of adding everolimus (EVE; Afinitor) plus letrozole (LET; Femara) to hormonal therapy for the treatment of premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (BC). The data showed that the combination of EVE+LET improved survival...
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In a nutshell This study examined the effectiveness of hormonal therapy in premenopausal women with hormone receptor-positive early breast cancer with or without other treatments. The authors concluded that patients who received hormonal therapy had a higher chance of survival and without a return of cancer. Some background The hormone...
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In a nutshell This study aimed to determine the effectiveness of goserelin (Zoladex) treatment with chemotherapy in young breast cancer patients. The study concluded that goserelin treatment with chemotherapy improved pathological complete response (pCR) rates. Some background A long-term and potentially devastating effect of chemotherapy...
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In a nutshell This article looked at the effects of endocrine therapy on hormonal changes during cancer treatment. Some background Hormone therapy to treat breast cancer is called endocrine therapy. This treatment is used in hormone receptor positive (HR+) early breast cancer. It causes changes to hormone signalling which can lead to early...
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In a nutshell This paper studied how suitable preimplantation genetic diagnosis was for patients who had mutations of the breast cancer 1 or 2 (BRCA1 or BRCA2) gene. Some background Hereditary breast and ovarian cancer (can be passed down from parent to child) are caused by mutations in genes called breast cancer 1 (BRCA1) and breast...
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In a nutshell This study investigated the effects of pregnancy following breast cancer diagnosis and treatment. Some background Nowadays, most breast cancer patients enjoy high survival rates and years of disease free quality of life. While the effects of breast cancer on fertility and pregnancy outcomes have been well researched, the effects of...
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In a nutshell This study evaluated whether taking a hormone called gonadotropin releasing hormone analog (GnRHa) during chemotherapy helps breast cancer patients preserve their fertility and prevent premature ovarian failure (POF). Some background In breast cancer, cells are dividing more rapidly than normal cells. Chemotherapy or medicines that...
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