In a nutshell This study examined the effect that restarting hormone treatment, as compared to stopping it, had on progression-free survival. It found that restarting treatment led to increased progression-free survival. Some background Breast cancer is classified into different subtypes depending on the prescence or absence of certain...
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In a nutshell This study aimed to compare fulvestrant (Faslodex) to other standard endocrine agents in patients with advanced hormone sensitive breast cancer. This study concluded that fulvestrant was as effective as the available standard endocrine agents. Some background Advanced hormone sensitive breast cancer (BC) is cancer that has...
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In a nutshell This study investigated the use of dexamethasone (Ozurdex) mouthwash for preventing stomatitis in patients with breast cancer(BC). The use of dexamethasone oral solution was found to significantly reduce the incidence and severity of stomatitis. Some background Everolimus (Afinitor) and exemestane (Aromasin) are mTOR inhibitors...
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In a nutshell This study looked at the effect of adding bevacizumab (Avastin) to letrozole (Femara) treatment in patients with hormone receptor-positive (HR+) metastatic (spread to other areas) breast cancer. They found that bevacizumab treatment prolonged the amount of time before patients experienced worsening of their...
Read MoreIn a nutshell The authors aimed to determine whether or not a hormone called melatonin could positively influence the quality of life of women with breast cancer. Some background Sleep disturbance is common among women with breast cancer. Melatonin is a hormone that induces sleepiness. This hormone is naturally found in our body but may decrease...
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In a nutshell This paper studied whether palbociclib (Ibrance) used in combination with letrozole (Femara) benefits breast cancer patients who are estrogen receptor positive (presence of receptor on cells) and human epidermal growth factor receptor 2 negative (absence of receptor on cells). Some background Estrogen receptor and human...
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In a nutshell This paper studied the impact of endocrine therapy on sexual function in postmenopausal patients with breast cancer. Some background Endocrine therapy is used in the treatment of hormone receptor positive early breast cancer. Hormone receptor positive breast cancer is cancer which has an abundant presence of the estrogen or...
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In a nutshell This paper studied the effect of aromatase inhibitors on cognitive function of older patients with breast cancer. Some background Aromatase inhibitors are drugs that block the activity of estrogen receptors (proteins on cells that react to the presence of the hormone estrogen). Not only do estrogen receptors promote cell growth...
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In a nutshell This paper reviewed adverse events associated with treatment of breast cancer with everolimus (Afinitus). Some background Everolimus is used in postmenopausal patients for advanced breast cancer treatments. The drug has been approved for use in patients with hormone receptor positive (the presence of the estrogen...
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In a nutshell This paper studies the ideal length of time needed for patients to receive letrozole (Femara) treatment to allow for breast conserving surgery. Some background Neoadjuvant chemotherapy (chemotherapy treatment given before primary treatment) compared with adjuvant chemotherapy (treatment given alongside...
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In a nutshell This study analyzed the association between the use of bisphosphonates and the risk of developing arterial fibrillation. Some background Osteoporosis, or a decrease in bone density (or strength), is common in postmenopausal women and even more so in cancer patients undergoing hormonal treatments or chemotherapy. Decreased bone...
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In a nutshell Researchers compared therapy with anastrozole (arimidex) and letrozole (femara) to determine the effects of these drugs on the quality of life (QoL) of breast cancer patients. Some background In the case of hormone receptor positive (HR+) breast cancer, patients typically receive surgery, followed by adjuvant (additional) treatment...
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