In a nutshell This study looked at the use of surgery for spread disease (metastases) in patients with advanced melanoma when other whole-body treatments had failed. It found that surgical removal of metastases improved the outcomes of these patients. Some background Advanced melanoma can spread to many places in the body. It is usually...
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In a nutshell The aim of this study was to check the safety and effectiveness of the combination of ipilimumab (Yervoy) and radiotherapy (RT) in patients with high-risk melanoma. The study found that ipilimumab + RT was safe and had good responses in these patients. Some background Melanoma is a type of skin cancer. First line therapy for...
Read MoreIn a nutshell This trial aims to test the effectiveness of pembrolizumab (Keytruda) before and after surgery in patients with high-risk melanoma. The main outcome that will be measured will be survival without cancer-related events. The details Pembrolizumab is an anti-cancer medication that targets the immune system. It helps the immune system...
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In a nutshell This study investigated the effect of nivolumab (Opdivo) combined with ipilimumab (Yervoy) in overall survival in the treatment of advanced melanoma. Researchers suggested that this combination is associated with an improved survival when compared to ipilimumab alone. Some background Advanced melanoma is associated with...
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In a nutshell The authors evaluated the efficacy and safety of intra-lesion IL-2 for in-transit cutaneous melanoma. Some background Approximately 10% of patients with locally advanced melanoma develop in-transit cutaneous metastases (melanoma deposits within the lymphatic vessels more than 2cm from the site of the primary melanoma). Eradication of...
Read MoreIn a nutshell This review analyzed data from several recent trials, and determined the benefit of liver resection (surgery to remove part or all of the liver) in patients with metastatic melanoma. Some background Melanoma is an uncontrolled growth of skin cells, but this cancer may also spread to other organs (referred to as metastatic melanoma)....
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