In a nutshell This study compared the safety and effectiveness of different doses of an oral insulin capsule formulation (Capsulin™) to patients with early-stage type 2 diabetes (T2D). The data showed that twice-daily, orally administered Capsulin at a dose of 150 international units (IU) was safe and resulted in a significant lowering...
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In a nutshell This study compared the effectiveness and safety of teneligliptin (Tenelia) to placebo in patients with type 2 diabetes (T2D) that was inadequately controlled with triple oral antidiabetic drugs (OADs). The study showed that teneligliptin may be considered as a fourth add-on OAD treatment in these patients. Some background T2D is...
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In a nutshell This study compared the effects of a ketogenic diet mobile health application (Keyto app) with breath acetone biofeedback (device) versus a calorie-restricted, low-fat diet (WW; weight watchers) app on weight loss and metabolic risk in patients with overweight or obesity. The data showed that a ketogenic diet app with a breath acetone...
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In a nutshell This study compared the effectiveness of chiglitazar (Bilessglu) and sitagliptin (Januvia) on glycemic (blood glucose) variations, insulin resistance, and inflammation levels in patients with type 2 diabetes (T2D). The data showed that chiglitazar treatment was more effective at improving insulin resistance and inflammation compared...
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In a nutshell This review looked at whether sodium-glucose cotransporter 2 (SGLT2) inhibitors can improve non-alcoholic fatty liver disease (NAFLD) for people with type 2 diabetes (T2D). It found that these medications can improve liver function in these patients. Some background NAFLD is a condition in which fat builds up in the liver. This makes the...
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In a nutshell This review focused on the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on heart failure hospitalization in patients with type 2 diabetes (T2D). This analysis showed that SGLT-2is may reduce the risk of heart failure hospitalizations in these patients. Some background Patients with T2D have a higher risk of developing...
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In a nutshell This review looked at how SGTL2 inhibitors with or without metformin (Glucophage) affect heart and kidney health for patients with type 2 diabetes (T2D). It found that these medications improve cardiovascular and kidney outcomes, whether or not patients are also taking metformin. Some background SGLT2 inhibitors are a group of T2D...
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In a nutshell This study examined the risk of major heart complications in patients taking a type of diabetic medication called DPP4-inhibitors. They found that patients taking DPP4-inhibitors were less likely to develop major heart disease than patients taking sulfonylureas. Some background Patients with type 2 diabetes (T2D) are at risk...
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In a nutshell This study examined the effectiveness and risks of polyethylene glycol loxenatide (PEX168) as an add-on to metformin (Glucophage) therapy in patients with type 2 diabetes (T2D). It found that PEX168 is safe and works effectively in improving the blood sugar levels in these patients. Some background T2D is a...
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In a nutshell This study evaluated whether adding vildagliptin (Galvus) to metformin (Glucophage) could improve the duration of blood glucose control for patients with newly diagnosed Type 2 Diabetes (T2D). The authors found that this treatment combination improved long-term blood glucose control for these patients. Some background...
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In a nutshell This study compared IDegLira (Xultophy) to insulin degludec (Tresiba) or liraglutide (Victoza) alone in patients with uncontrolled Type 2 diabetes (T2D). The authors concluded that combined IDegLira was more effective and had fewer side effects than either insulin medication alone. Some background One of the main...
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In a nutshell This study compared insulin degludec/liraglutide (IDegLira) to standard insulin in patients with uncontrolled Type 2 diabetes (T2D). The authors concluded that IDegLira improved patient compliance to treatment and reduced treatment-related stress compared to conventional insulin. Some background One of the main goals of treatment...
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