In a nutshell This study evaluated the effectiveness and safety of aprocitentan (ACT-132577) for lowering blood pressure (BP) in patients with resistant or uncontrolled hypertension (high BP). The data showed that aprocitentan was effective in lowering the BP after 4 weeks with a sustained effect after 40 weeks compared to a placebo with...
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In a nutshell This study looked at the use of renal denervation in patients with true resistant hypertension. It found that this procedure reduced blood pressure compared to medicine alone. Some background High blood pressure (BP) which is not controlled on three blood pressure-lowering medications including a diuretic (water pill) is...
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In a nutshell This study looked at the use of renal denervation surgery (RDS) in patients with resistant hypertension. They found that after 12 months RDS led to a significant drop in blood pressure in these patients. Some background Resistant hypertension is high blood pressure that is not controlled despite using at least 3 different blood pressure...
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In a nutshell This trial is aiming to assess the effectiveness and safety of a new drug (CIN-107) in patients with treatment-resistant hypertension (rHTN). The main outcome that will be measured is the change in blood pressure over a time-frame of 12-weeks. This trial is being carried out in the United States. The details Resistant...
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In a nutshell This study looked at how effectively spironolactone (Aldactone) lowers blood pressure (BP) in patients with resistant hypertension (RH). They found that spironolactone significantly lowers BP in some patients after three months. Some background High BP can lead to strokes and heart attacks. There are many types of...
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In a nutshell This study was carried out to look at the effect that drug treatments have on the quality of life (QoL) of patients with benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS). The authors found that in patients with LUTS/BPE, surgery should be carried out earlier in patients who do not respond to medical...
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In a nutshell This study looked at the association between antidepressant medication and abnormal bleeding. The authors stated that antidepressants increase the risk of abnormal bleeding, particularly when combined with nonsteroidal anti-inflammatory drugs (NSAIDs). Some background Serotonin reuptake inhibitors (SRIs) are used to treat...
Read MoreIn a nutshell This study looked at using a combination of alpha blockers (AB) and phosphodiesterase type 5 inhibitors (PDE5I) to treat lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) symptoms. This study concluded that combination therapy of these drugs could improve symptoms. Some background Benign Prostatic...
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In a nutshell This study looked at the effect of adding dutasteride (Avodart) to patients already on ineffective drug treatment for an enlarged prostate and bladder symptoms. The study found that adding dutasteride reduced detrusor (muscle of the bladder) size and bladder problems. Some background Patients with enlarged prostates and urinary...
Read MoreIn a nutshell This study looked at the effect of injecting botulinum toxin type A (BTA) into patients to treat enlarged prostate who did not respond to medical therapy such as drug treatment. The study found that BTA injection was safe and effective at reducing several urinary symptoms in patients with enlarged prostates. Some background Benign...
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In a nutshell This study examined a possible link between suicidality and depression and the use of 5-alpha reductase inhibitors (5ARIs) for benign prostatic hyperplasia (BPH). Researchers reported no link between suicide risk and 5ARI use. However, the risk of self-harm and depression was significantly increased among men using a 5ARI compared to men...
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In a nutshell This study examined the effects of combining tadalafil (Cialis) with silodosin (Rapaflo) for benign prostatic hyperplasia (BPH). Researchers reported improved urinary symptoms when tadalafil was added to silodosin treatment compared to silodosin alone. Some background Men with BPH often experience urinary symptoms that can...
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